Novel anti-glycation therapeutic agents: glyoxalase I mimetics

被引：13

作者：

Battah, S ^{[1
]}

Ahmed, N ^{[1
]}

Thornalley, PJ ^{[1
]}

机构：

[1] Univ Essex, Dept Sci Biol, Colchester CO4 3SQ, Essex, England

来源：

MAILLARD REACTION IN FOOD CHEMISTRY AND MEDICAL SCIENCE: UPDATE FOR THE POSTGENOMIC ERA | 2002年 / 1245卷

关键词：

glyoxalase; histidine; carnosine; methylglyoxal; glycation;

D O I：

10.1016/S0531-5131(02)00884-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glyoxalase I mimetic activity has been associated with the imidazole function. Histidine, histidine methyl ester and carnosine had glyoxalase I mimetic activity under physiological conditions. Carnosine scavenged methylglyoxal to form beta-alanyl-N-DL-lactoyl-L-histidine (lactoyl-camosine). This scavenging of alpha-oxoaldehydes by carnosine, and hydrolysis of the adduct formed to the corresponding aldonic acid catalysed by acyl-histidine hydrolase, represented a glyoxalase system mimetic activity. Glyoxalase mimetics are novel anti-glycation agents that may have therapeutic applications. Their specific activity, however, needs to be improved to have significant pharmacological effect. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：107 / 111

页数：5

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