Recent Advances in Antifouling Materials for Surface Plasmon Resonance Biosensing in Clinical Diagnostics and Food Safety

被引：42

作者：

D'Agata, Roberta ^{[1
]}

Bellassai, Noemi ^{[1
]}

Jungbluth, Vanessa ^{[1
]}

Spoto, Giuseppe ^{[1
,2
]}

机构：

[1] Univ Catania, Dipartimento Sci Chim, Viale Andrea Doria 6, I-95125 Catania, Italy

[2] Univ Catania, Consorzio Interuniv Ist Nazl Biostrutture & Biosi, Dipartimento Sci Chim, Viale Andrea Doria 6, I-95125 Catania, Italy

来源：

POLYMERS | 2021年 / 13卷 / 12期

基金：

欧盟地平线“2020”;

关键词：

antifouling; surface plasmon resonance; clinical diagnosis; food safety; biosensing; POLY-L-LYSINE; FOODBORNE BACTERIAL PATHOGENS; IMAGING-BASED BIOSENSOR; OF-THE-ART; ULTRASENSITIVE DETECTION; FOULING SURFACE; LIQUID BIOPSY; BLOOD-PLASMA; PROTEIN IMMOBILIZATION; POLY(ETHYLENE OXIDE);

D O I：

10.3390/polym13121929

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Strategies to develop antifouling surface coatings are crucial for surface plasmon resonance (SPR) sensing in many analytical application fields, such as detecting human disease biomarkers for clinical diagnostics and monitoring foodborne pathogens and toxins involved in food quality control. In this review, firstly, we provide a brief discussion with considerations about the importance of adopting appropriate antifouling materials for achieving excellent performances in biosensing for food safety and clinical diagnosis. Secondly, a non-exhaustive landscape of polymeric layers is given in the context of surface modification and the mechanism of fouling resistance. Finally, we present an overview of some selected developments in SPR sensing, emphasizing applications of antifouling materials and progress to overcome the challenges related to the detection of targets in complex matrices relevant for diagnosis and food biosensing.

引用

页数：24