Advances on CD8+ Treg Cells and Their Potential in Transplantation

被引：48
作者：
Bezie, Severine [1 ,2 ,3 ]
Anegon, Ignacio [1 ,2 ,3 ]
Guillonneau, Carole [1 ,2 ,3 ]
机构：
[1] Univ Nantes, Ctr Rech Transplantat & Immunol, INSERM, Nantes, France
[2] CHU Nantes, ITUN, Nantes, France
[3] LabEx IGO Immunotherapy Graft Oncol, Nantes, France
来源：
TRANSPLANTATION | 2018年 / 102卷 / 09期
关键词：
REGULATORY T-CELLS; VERSUS-HOST-DISEASE; GROWTH-FACTOR-BETA; DENDRITIC CELLS; IFN-GAMMA; SUPPRESSOR-CELLS; ALLOGRAFT-REJECTION; PROMOTES TOLERANCE; IMMUNE SUPPRESSION; CENTRAL MEMORY;
D O I：
10.1097/TP.0000000000002258
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Although cluster of differentiation (CD)8(+) regulatory T (Treg) cells have been in the last 20 years more studied since evidences of their role in tolerance as been demonstrated in transplantation, autoimmune diseases and cancer, their characteristics are still controversial. In this review, we will focus on recent advances on CD8(+) Treg cells and description of a role for CD8(+) Treg cells in tolerance in both solid organ transplantation and graft-versus-host disease and their potential for clinical trials.
引用
收藏
页码：1467 / 1478
页数：12
相关论文
共 162 条
[1]   CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity [J].
Akane, Kazuyuki ;
Kojima, Seiji ;
Mak, Tak W. ;
Shiku, Hiroshi ;
Suzuki, Haruhiko .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (09) :2460-2465
[2]   Low-Dose IL-2 for In Vivo Expansion of CD4+ and CD8+ Regulatory T Cells in Nonhuman Primates [J].
Aoyama, A. ;
Klarin, D. ;
Yamada, Y. ;
Boskovic, S. ;
Nadazdin, O. ;
Kawai, K. ;
Schoenfeld, D. ;
Madsen, J. C. ;
Cosimi, A. B. ;
Benichou, G. ;
Kawai, T. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2012, 12 (09) :2532-2537
[3]   Disruption of CD8+ Treg Activity Results in Expansion of T Follicular Helper Cells and Enhanced Antitumor Immunity [J].
Arias, Diana A. Alvarez ;
Kim, Hye-Jung ;
Zhou, Penghui ;
Holderried, Tobias A. W. ;
Wang, Xuan ;
Dranoff, Glenn ;
Cantor, Harvey .
CANCER IMMUNOLOGY RESEARCH, 2014, 2 (03) :207-216
[4]   Phenotypically and functionally distinct CD8+ lymphocyte populations in long-term drug-free tolerance and chronic rejection in human kidney graft recipients [J].
Baeten, Dominique ;
Louis, Stephanie ;
Braud, Christophe ;
Braudeau, Cecile ;
Ballet, Caroline ;
Moizant, Frederic ;
Pallier, Annaik ;
Giral, Magali ;
Brouard, Sophie ;
Soulillou, Jean-Paul .
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (01) :294-304
[5]   Ectonucleotidase CD38 Demarcates Regulatory, Memory-Like CD8+ T Cells with IFN-γ-Mediated Suppressor Activities [J].
Bahri, Rajia ;
Bollinger, Annalena ;
Bollinger, Thomas ;
Orinska, Zane ;
Bulfone-Paus, Silvia .
PLOS ONE, 2012, 7 (09)
[6]   Alloanergization of Human T Cells Results in Expansion of Alloantigen-Specific CD8+CD28- Suppressor Cells [J].
Barbon, C. M. ;
Davies, J. K. ;
Voskertchian, A. ;
Kelner, R. H. ;
Brennan, L. L. ;
Nadler, L. M. ;
Guinan, E. C. .
AMERICAN JOURNAL OF TRANSPLANTATION, 2014, 14 (02) :305-318
[7]   Human CD4+CD25+Foxp3+ Regulatory T Cells Do Not Constitutively Express IL-35 [J].
Bardel, Emilie ;
Larousserie, Frederique ;
Charlot-Rabiega, Pascaline ;
Coulomb-L'Hermine, Aurore ;
Devergne, Odile .
JOURNAL OF IMMUNOLOGY, 2008, 181 (10) :6898-6905
[8]   CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria [J].
Barnes, M. J. ;
Griseri, T. ;
Johnson, A. M. F. ;
Young, W. ;
Powrie, F. ;
Izcue, A. .
MUCOSAL IMMUNOLOGY, 2013, 6 (02) :324-334
[9]   Rapamycin selectively expands CD4+CD25+FoxP3+ regulatory T cells [J].
Battaglia, M ;
Stabilini, A ;
Roncarolo, MG .
BLOOD, 2005, 105 (12) :4743-4748
[10]   CD8+ Foxp3+ Regulatory T Cells Are Induced during Graft-versus-Host Disease and Mitigate Disease Severity [J].
Beres, Amy J. ;
Haribhai, Dipica ;
Chadwick, Alexandra C. ;
Gonyo, Patrick J. ;
Williams, Calvin B. ;
Drobyski, William R. .
JOURNAL OF IMMUNOLOGY, 2012, 189 (01) :464-474
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