The tracking of interfacial interaction of amorphous solid dispersions formed by water-soluble polymer and nitrendipine

被引：17
作者：
Li, Jing [1 ]
Fan, Na [1 ]
Li, Chang [1 ]
Wang, Jian [3 ]
Li, Sanming [2 ]
He, Zhonggui [1 ]
机构：
[1] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang, Liaoning, Peoples R China
[2] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Liaoning, Peoples R China
[3] Shenyang Pharmaceut Univ, Key Lab Struct Based Drug Design & Discovery, Shenyang, Liaoning, Peoples R China
来源：
APPLIED SURFACE SCIENCE | 2017年 / 420卷
关键词：
Amorphous solid dispersions; Interfacial interaction; Dissolution mechanism; ORAL BIOAVAILABILITY; DRUG-RELEASE; ENHANCEMENT; MECHANISMS; CRYSTALLIZATION; DISSOLUTION; SOLUBILITY; STABILITY; CARRIERS; STRATEGY;
D O I：
10.1016/j.apsusc.2017.05.123
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Herein, interfacial interactions of amorphous solid dispersion formed by nitrendipine (TDP) and two types of water-soluble polymers (polyvinyl pyrrolidone K30 (PVP) and polyethylene glycol 6000 (PEG)) were tracked mainly concerning with interaction forces and wetting process. Infrared spectroscopy (IR), raman spectroscopy and contact angle instrument were mainly used through the study. Hydrogen bonding forces were formed between drug and excipient in TDP-PVP and TDP-PEG. The red raman shift of TDP-PVP and TDP-PEG confirmed the hydrogen bonding forces between TDP and the two polymers. Both TDP-PVP and TDP-PEG showed higher drug release and TDP-PVP accomplished TDP release faster due to its better drug amorphous state. It is believed that the track of interfacial interactions will certainly become powerful tools to provide valuable instruction for designing and evaluating amorphous solid dispersions. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：136 / 144
页数：9
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