Genetics of Obsessive-Compulsive Disorder

被引：65

作者：

Nestadt, Gerald ^{[1
]}

Grados, Marco ^{[1
]}

Samuels, Jack F. ^{[1
]}

机构：

[1] Johns Hopkins Univ Hosp, Dept Psychiat & Behav Sci, Johns Hopkins Sch Med, Baltimore, MD 21287 USA

来源：

PSYCHIATRIC CLINICS OF NORTH AMERICA | 2010年 / 33卷 / 01期

关键词：

Obsessive-compulsive disorder; Genetics; Psychiatry; SEROTONIN TRANSPORTER GENE; FAMILY-BASED ASSOCIATION; 5-HT2A PROMOTER POLYMORPHISM; COMPLEX SEGREGATION ANALYSIS; RECEPTOR GENE; DECISION-MAKING; DOUBLE-BLIND; LINKAGE DISEQUILIBRIUM; COGNITIVE FLEXIBILITY; PSYCHIATRIC-DISORDERS;

D O I：

10.1016/j.psc.2009.11.001

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Obsessive-compulsive disorder is a common debilitating condition affecting individuals from childhood through adult life. There is good evidence of genetic contribution to its etiology, but environmental risk factors also are likely to be involved. The condition probably has a complex pattern of inheritance. Molecular studies have identified several potentially relevant genes, but much additional research is needed to establish definitive causes of the condition.

引用

页码：141 / +

页数：19

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