The T-cell protein tyrosine phosphatase

被引：81

作者：

Ibarra-Sánchez, MD

Simoncic, PD

Nestel, FR

Duplay, P

Lapp, WS

Tremblay, ML ^{[1
]}

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[2] McGill Univ, Dept Physiol, Montreal, PQ H3G 1Y6, Canada

[3] Univ Quebec, Inst Armand Frappier, Laval, PQ H7V 1B7, Canada

来源：

SEMINARS IN IMMUNOLOGY | 2000年 / 12卷 / 04期

基金：

英国医学研究理事会;

关键词：

gene targeting; signal transduction; T- and B-cell development; T-cell protein tyrosine phosphatase;

D O I：

10.1006/smim.2000.0220

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In recent years, the T-cell protein tyrosine phosphatase (TC-PTP) has become an important member of the protein-tyrosine phosphatase (PTP) family in two aspects. Firstly, TC-PTP has been reported to act on downstream signalling events initiated by the epidermal growth receptor, suggesting that it may act as an important modulator of receptor tyrosine Kinases and mitogenic signalling. Secondly, the finding of immune deficiency and lethality observed in TC-PTP null mice emphasizes the importance of this small PTP in the hematopoietic system. In this review, we provide a summary of the recent literature published on the TC-PTP and its various orthologs. Although much remains to be uncovered some recent findings on the function of this small PTP suggest that it plays a critical role in regulating mammalian cell signalling.

引用

收藏

页码：379 / 386

页数：8

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