Preparation and evaluation of chitosan/β-cyclodextrin magnetic nanoparticles as a photodegradable and hydrophobic drug delivery carrier

In this study, novel tumor targeting nanocarriers comprised of chitosan (CS)/beta-cyclodextrin (beta-CD) magnetic nanoparticles were prepared to improve the photodegradable stability and bioavailability of hydrophobic drug. Resveratrol (Res) with photodegradable and hydrophobic properties was selected as a model drug. The photodegradation rate of Res in Fe3O4 nanoparticles solution was 7.8 times lower than that in the ethanol solution. In addition, the value of the saturation magnetization of CS/beta-CD nanoparticles was found to be 19.56 emu/g with characteristic of superparamagnetism. Approximately 90% Res was entrapped into the CS/beta-CD magnetic nanoparticles with the size distribution ranging from 200 to 359 nm, and the nanoparticles were spherical in shape with high zeta potentials. Furthermore, the formation of CS/beta-CD nanoparticles showed a sustained release in vitro. These results indicated that the obtained CS/beta-CD magnetic nanoparticles were a promising magnetic targeting carrier for photodegradable and hydrophobic drugs. (C) 2017 Wiley Periodicals, Inc.