Preparation and evaluation of chitosan/β-cyclodextrin magnetic nanoparticles as a photodegradable and hydrophobic drug delivery carrier

被引:11
|
作者
Shi, Xu [1 ]
Xiang, Cuncheng [1 ]
Liu, Yuehua [1 ]
Lin, Huihuan [1 ]
Xu, Yi [1 ]
Ji, Jingou [1 ]
机构
[1] Univ Chongqing, Fac Pharmaceut Engn, Coll Chem & Chem Engn, Chongqing 400030, Peoples R China
关键词
chitosan; beta-cyclodextrin; magnetic nanoparticles; photodegradable drugs; IN-VITRO; TUMOR-GROWTH; RELEASE; CELLS; ACID; PHOTOSTABILITY; ENCAPSULATION; APOPTOSIS; MICELLES; COMPLEX;
D O I
10.1002/app.45076
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
In this study, novel tumor targeting nanocarriers comprised of chitosan (CS)/beta-cyclodextrin (beta-CD) magnetic nanoparticles were prepared to improve the photodegradable stability and bioavailability of hydrophobic drug. Resveratrol (Res) with photodegradable and hydrophobic properties was selected as a model drug. The photodegradation rate of Res in Fe3O4 nanoparticles solution was 7.8 times lower than that in the ethanol solution. In addition, the value of the saturation magnetization of CS/beta-CD nanoparticles was found to be 19.56 emu/g with characteristic of superparamagnetism. Approximately 90% Res was entrapped into the CS/beta-CD magnetic nanoparticles with the size distribution ranging from 200 to 359 nm, and the nanoparticles were spherical in shape with high zeta potentials. Furthermore, the formation of CS/beta-CD nanoparticles showed a sustained release in vitro. These results indicated that the obtained CS/beta-CD magnetic nanoparticles were a promising magnetic targeting carrier for photodegradable and hydrophobic drugs. (C) 2017 Wiley Periodicals, Inc.
引用
收藏
页数:7
相关论文
共 50 条
  • [21] Chitosan nanoparticles for combined drug delivery and magnetic hyperthermia: From preparation to in vitro studies
    Zamora-Mora, Vanessa
    Fernandez-Gutierrez, Mar
    Gonzalez-Gomez, Alvaro
    Sanz, Beatriz
    San Roman, Julio
    Goya, Gerardo F.
    Hernandez, Rebeca
    Mijangos, Carmen
    CARBOHYDRATE POLYMERS, 2017, 157 : 361 - 370
  • [22] Preparation and characterization of galactosylated chitosan nanoparticles as a targeting drug carrier
    Zheng, Fei
    Ling, Kai
    Li, Junli
    Chen, Jinghua
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2007, 234
  • [23] Grafting of 2-Hydroxypropyl-β-Cyclodextrin on Gum Arabic-Modified Iron Oxide Nanoparticles as a Magnetic Carrier for Targeted Delivery of Hydrophobic Anticancer Drug
    Banerjee, Shashwat S.
    Chen, Dong-Hwang
    INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY, 2010, 7 (01) : 111 - 118
  • [24] Novel nanoparticles composed of chitosan and β-cyclodextrin derivatives as potential insoluble drug carrier
    Yan-Zuo Chen
    Yu-Kun Huang
    Yuan Chen
    Ya-Jing Ye
    Kai-Yan Lou
    Feng Gao
    ChineseChemicalLetters, 2015, 26 (07) : 909 - 913
  • [25] Novel nanoparticles composed of chitosan and β-cyclodextrin derivatives as potential insoluble drug carrier
    Chen, Yan-Zuo
    Huang, Yu-Kun
    Chen, Yuan
    Ye, Ya-Jing
    Lou, Kai-Yan
    Gao, Feng
    CHINESE CHEMICAL LETTERS, 2015, 26 (07) : 909 - 913
  • [26] Preparation of Chitosan Nanoparticles as a Capable Carrier for Antigen Delivery and Antibody Production
    Mirtajaddini, Seyyed Aliakbar
    Najafi, Mohsen Fathi
    Yazdi, Seyed Ali Vaziri
    Oskuee, Reza Kazemi
    IRANIAN JOURNAL OF BIOTECHNOLOGY, 2021, 19 (04) : 32 - 40
  • [27] Preparation and evaluation of photocrosslinkable chitosan as a drug delivery matrix
    Jameela, SR
    Lakshmi, S
    James, NR
    Jayakrishnan, A
    JOURNAL OF APPLIED POLYMER SCIENCE, 2002, 86 (08) : 1873 - 1877
  • [28] Stealth PEGylated chitosan polyelectrolyte complex nanoparticles as drug delivery carrier
    Deng, Xingyue
    Zhao, Jing
    Liu, Kaiwen
    Wu, Chao
    Liang, Fei
    JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION, 2021, 32 (11) : 1387 - 1405
  • [29] Preparation of Biocompatible Carboxymethyl Chitosan Nanoparticles for Delivery of Antibiotic Drug
    Zhao, Liang
    Zhu, Bingya
    Jia, Yunhong
    Hou, Wenjiu
    Su, Chang
    BIOMED RESEARCH INTERNATIONAL, 2013, 2013
  • [30] Preparation of chitosan nanoparticles as a drug delivery system for perindopril erbumine
    Hussein-Al-Ali, Samer Hasan
    Kura, Aminu
    Hussein, Mohd Zobir
    Fakurazi, Sharida
    POLYMER COMPOSITES, 2018, 39 (02) : 544 - 552