Successful Treatment of Disseminated Invasive Aspergillosis with Itraconazole in a Severe Chronic Hepatitis B Patient

Invasive aspergillosis is a rapid, progressive, and often fatal disease that usually affects immunocompromised patients. Opportunistic invasive fungal infections can occur in patients with severe diseases, such as severe hepatic disease although they are immunocompetent. We report a successful case of treatment with itraconazole for a 31-year-old patient with severe chronic hepatitis B (CHB) complicated with disseminated aspergillosis that rapidly progressed to affect his respiratory and central nervous systems as well as the eye. We discussed our experience and recognized that invasive aspergillosis should be considered in severe CHB patients who develop acute respiratory failure or uncontrollable pulmonary infection.