The role of cytotoxic T lymphocytes in human T-cell lymphotropic virus type 1 infection

被引：25

作者：

Asquith, B ^{[1
]}

Bangham, CRM ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Sch Med, Dept Immunol, London W2 1PG, England

来源：

JOURNAL OF THEORETICAL BIOLOGY | 2000年 / 207卷 / 01期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/jtbi.2000.2156

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The vast majority of individuals infected with human T-cell lymphotropic virus type 1 have a strong and persistently activated cytotoxic T lymphocyte response to the virus. Experimental work investigating the effects of human T-cell lymphotropic virus-specific cytotoxic T lymphocytes is conflicting. One significant body of work suggests that specific cytotoxic T lymphocytes are protective and help to reduce the risk of disease. However, another body of work implies that specific cytotoxic T lymphocytes play an important role in the development of disease. Here we use a theoretical model to explore the role of cytotoxic T lymphocytes in persistent infection. A way of reconciling the apparently contradictory data is proposed and experimentally testable predictions are made. (C) 2000 Academic Press.

引用

收藏

页码：65 / 79

页数：15

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