New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity

被引：7
作者：
Shao Si-Yuan [1 ]
Li Ruo-Fei [1 ]
Sun Hua [1 ]
Li Shuai [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100730, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2021年 / 19卷 / 05期
关键词：
Ilex chinensis; Ursane and oleanane; Triterpenoid saponins; Hepatoprotective activity;
D O I：
10.1016/S1875-5364(21)60036-5
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Seven new triterpenoid saponins, including five ursane-type saponins, ilexchinenosides R-V (1-5), and two oleanane-type saponins, ilexchinenosides W-X (6-7), with four known triterpenoid saponins (8-11) were isolated from the leaves of Ilex chinensis. Their structures were elucidated by comprehensive spectroscopic 1D and 2D NMR and HR-ESI-MS data. Their sugar moieties were determined by HPLC analysis compared with standards after hydrolysis and derivatization. Compounds 1, 2, 4, 9 and 10 exhibited potential hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell injury in vitro.
引用
收藏
页码：376 / 384
页数：9
相关论文
共 50 条
  • [41] Two new triterpenoid saponins from Adina pilulifera
    Shi, HM
    Min, ZD
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2003, 5 (01) : 11 - 16
  • [42] New Triterpenoid Saponins from the Roots of Saponaria officinalis
    Moniuszko-Szajwaj, Barbara
    Pecio, Lukasz
    Kowalczyk, Mariusz
    Simonet, Ana M.
    Macias, Francisco A.
    Szumacher-Strabel, Malgorzata
    Cieslak, Adam
    Oleszek, Wieslaw
    Stochmal, Anna
    NATURAL PRODUCT COMMUNICATIONS, 2013, 8 (12) : 1687 - 1690
  • [43] Triterpenoid saponins from the leaves and stems of Pericampylus glaucus and their insulin mimetic activities
    Lee, Hee-Ju
    Cho, Hyo-Moon
    Park, Eun-Jin
    Lee, Ba-Wool
    Duc-Trong Nghiem
    Ha-Thanh-Tung Pham
    Pan, Cheol-Ho
    Oh, Won-Keun
    BIOORGANIC CHEMISTRY, 2021, 117
  • [44] Mechanism of antiviral activity of triterpenoid saponins
    Simoes, CMO
    Amoros, M
    Girre, L
    PHYTOTHERAPY RESEARCH, 1999, 13 (04) : 323 - 328
  • [45] Central and peripheral analgesic active components of triterpenoid saponins from Stauntonia chinensis and their action mechanism
    Gong, Ji-Hong
    Zhang, Chang-Ming
    Wu, Bo
    Zhang, Zi-Xun
    Zhou, Zhong-Yan
    Zhu, Jia-Hui
    Liu, Han
    Rong, Yi
    Yin, Qian
    Chen, Ya-Ting
    Zheng, Rong
    Yang, Guang-Zhong
    Yang, Xiao-Fei
    Chen, Su
    FRONTIERS IN PHARMACOLOGY, 2023, 14
  • [46] Bioactive Triterpenoid Saponins From the Seeds of Aesculus chinensis Bge. var. chekiangensis
    Zhang, Nan
    Wei, Shuxiang
    Cao, Shijie
    Zhang, Qiang
    Kang, Ning
    Ding, Liqin
    Qiu, Feng
    FRONTIERS IN CHEMISTRY, 2020, 7
  • [47] New triterpenoid saponins with cytotoxic activities from Ligularia przewalskii
    Shi, Zhuan-Ning
    Wang, Yu-Dong
    Gong, Yuan
    Li, Hong-Fang
    Zhu, Ying
    PHYTOCHEMISTRY LETTERS, 2019, 30 : 215 - 219
  • [48] Three new triterpenoid saponins from the seeds of Vaccaria segetalis
    Sang, SM
    Lao, AN
    Chen, ZL
    Uzawa, J
    Fujimoto, Y
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2000, 2 (03) : 187 - 193
  • [49] New triterpenoid saponins from the stem bark of Hallea ledermannii
    Koffi, Jean-Michel Kouame
    Yao-Kouassi, Philomene Akoua
    Magid, Abdulmagid Alabdul
    Akissi, Zachee Louis Evariste
    Martinez, Agathe
    Sayagh, Charlotte
    Voutquenne-Nazabadioko, Laurence
    TETRAHEDRON LETTERS, 2023, 116
  • [50] Two new triterpenoid saponins from the flowers of Albizia lebbeck
    Viana, Elaine O. R.
    da Silva, Marilia J.
    da Silva, Bernadete P.
    Tinoco, Luzineide W.
    Parente, Jose P.
    NATURAL PRODUCT RESEARCH, 2023, 37 (13) : 2151 - 2160
12345