New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity

被引：7
作者：
Shao Si-Yuan [1 ]
Li Ruo-Fei [1 ]
Sun Hua [1 ]
Li Shuai [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100730, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2021年 / 19卷 / 05期
关键词：
Ilex chinensis; Ursane and oleanane; Triterpenoid saponins; Hepatoprotective activity;
D O I：
10.1016/S1875-5364(21)60036-5
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Seven new triterpenoid saponins, including five ursane-type saponins, ilexchinenosides R-V (1-5), and two oleanane-type saponins, ilexchinenosides W-X (6-7), with four known triterpenoid saponins (8-11) were isolated from the leaves of Ilex chinensis. Their structures were elucidated by comprehensive spectroscopic 1D and 2D NMR and HR-ESI-MS data. Their sugar moieties were determined by HPLC analysis compared with standards after hydrolysis and derivatization. Compounds 1, 2, 4, 9 and 10 exhibited potential hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell injury in vitro.
引用
收藏
页码：376 / 384
页数：9
相关论文
共 50 条
  • [31] Structural determination of two new triterpenoid saponins acylated with monoterpenic acid from Gymnocladus chinensis Baill.
    Qi, Wen
    Yuan, Dan
    Yang, Lian-Mei
    Xie, Ke-Hui
    Cai, Tian-Zhi
    Yang, Rong
    Fu, Hong-Zheng
    NATURAL PRODUCT RESEARCH, 2012, 26 (15) : 1436 - 1441
  • [32] In vitro antiproliferative activity of triterpenoid saponins from leaves of Hedera helix L. grown in Romania
    Tatia, Rodica
    Tarcomnicu, Isabela
    Moldovan, Zenovia
    Raiciu, Anca Daniela
    Moldovan, Lucia
    Zalaru, Christina Marie
    SOUTH AFRICAN JOURNAL OF BOTANY, 2023, 158 : 1 - 7
  • [33] New triterpenoid saponins from bulbs of Bolbostemma paniculatum
    Liu, WY
    Zhang, WD
    Chen, HS
    Gu, ZB
    Li, TZ
    Chen, WS
    PLANTA MEDICA, 2004, 70 (05) : 458 - 464
  • [34] NEW TRITERPENOID SAPONINS FROM HELIANTHUS-ANNUUS
    BADER, G
    ZIESCHANG, M
    WAGNER, K
    GRUNDEMANN, E
    HILLER, K
    PLANTA MEDICA, 1991, 57 (05) : 471 - 474
  • [35] New triterpenoid saponins with strong α-glucosidase inhibitory activity from the roots of Gypsophila oldhamiana
    Luo, Han-Guang
    Ma, Li
    Kong, Ling-Yi
    BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (06) : 2912 - 2920
  • [36] Two new triterpenoid saponins from Glochidion puberum
    Zhang, Zhen
    Gao, Zhu-Lin
    Fang, Xin
    Wang, Yue-Hu
    Xiao, Huai
    Hao, Xiao-Jiang
    Liu, Guang-Ming
    He, Hong-Ping
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2008, 10 (11) : 1029 - 1034
  • [37] New triterpenoid saponins from the flowers of Pueraria thomsonii
    Lu, Jing
    Sun, Jia-Hong
    Tan, Yao
    Kano, Yoshihiro
    Yuan, Dan
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2013, 15 (10) : 1065 - 1072
  • [38] Four new triterpenoid saponins from Ardisia gigantifolia Stapf. and their cytotoxic activity
    Wen, Ping
    Zhang, Xiao-Ming
    Yang, Zhu
    Wang, Nai-Li
    Yao, Xin-Sheng
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2008, 10 (09) : 873 - 880
  • [39] Two new triterpenoid saponins from Centella asiatica
    Ren, Bo
    Luo, Wei
    Xie, Meng-jun
    Zhang, Mei
    PHYTOCHEMISTRY LETTERS, 2021, 44 : 102 - 105
  • [40] Five New Triterpenoid Saponins from the Rhizomes of Panacis majoris and Their Antiplatelet Aggregation Activity
    Li, Min
    Liu, Fen
    Jin, Yong-Ri
    Wang, Xiao-Zhong
    Wu, Qian
    Liu, Ying
    Li, Xu-Wen
    PLANTA MEDICA, 2017, 83 (3-4) : 351 - 357
12345