New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity

被引：7
作者：
Shao Si-Yuan [1 ]
Li Ruo-Fei [1 ]
Sun Hua [1 ]
Li Shuai [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100730, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2021年 / 19卷 / 05期
关键词：
Ilex chinensis; Ursane and oleanane; Triterpenoid saponins; Hepatoprotective activity;
D O I：
10.1016/S1875-5364(21)60036-5
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Seven new triterpenoid saponins, including five ursane-type saponins, ilexchinenosides R-V (1-5), and two oleanane-type saponins, ilexchinenosides W-X (6-7), with four known triterpenoid saponins (8-11) were isolated from the leaves of Ilex chinensis. Their structures were elucidated by comprehensive spectroscopic 1D and 2D NMR and HR-ESI-MS data. Their sugar moieties were determined by HPLC analysis compared with standards after hydrolysis and derivatization. Compounds 1, 2, 4, 9 and 10 exhibited potential hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell injury in vitro.
引用
收藏
页码：376 / 384
页数：9
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