New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity

被引：7
|
作者：
Shao Si-Yuan [1 ]
Li Ruo-Fei [1 ]
Sun Hua [1 ]
Li Shuai [1 ]
机构：
[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100730, Peoples R China
来源：
CHINESE JOURNAL OF NATURAL MEDICINES | 2021年 / 19卷 / 05期
关键词：
Ilex chinensis; Ursane and oleanane; Triterpenoid saponins; Hepatoprotective activity;
D O I：
10.1016/S1875-5364(21)60036-5
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Seven new triterpenoid saponins, including five ursane-type saponins, ilexchinenosides R-V (1-5), and two oleanane-type saponins, ilexchinenosides W-X (6-7), with four known triterpenoid saponins (8-11) were isolated from the leaves of Ilex chinensis. Their structures were elucidated by comprehensive spectroscopic 1D and 2D NMR and HR-ESI-MS data. Their sugar moieties were determined by HPLC analysis compared with standards after hydrolysis and derivatization. Compounds 1, 2, 4, 9 and 10 exhibited potential hepatoprotective activity against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell injury in vitro.
引用
收藏
页码：376 / 384
页数：9
相关论文
共 50 条
  • [1] New triterpenoid saponins from the leaves of Ilex chinensis and their hepatoprotective activity
    SHAO Si-Yuan
    LI Ruo-Fei
    SUN Hua
    LI Shuai
    ChineseJournalofNaturalMedicines, 2021, 19 (05) : 376 - 384
  • [2] New triterpenoid saponins from the leaves of Ilex chinensis
    Li, Ruo-Fei
    Xia, Wen-Qi
    Liu, Jia-Bao
    Cui, Bao-Song
    Hou, Qi
    Sun, Hua
    Li, Shuai
    FITOTERAPIA, 2018, 131 : 134 - 140
  • [3] Two new triterpenoid saponins from the leaves of Ilex kudingcha
    Zuo, Wen-Jian
    Dai, Hao-Fu
    Zeng, Yan-Bo
    Wang, Hui
    Chen, Hui-Qin
    Wang, Jin-Hui
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2012, 14 (04) : 308 - 313
  • [4] Triterpenoid saponins from the leaves of Ilex latifolia
    Ouyang, MA
    Wang, HQ
    Liu, YQ
    Yang, CR
    PHYTOCHEMISTRY, 1997, 45 (07) : 1501 - 1505
  • [5] Triterpenoid saponins from the leaves of Ilex kudincha
    Ouyang, MA
    Yang, CR
    Wu, ZJ
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2001, 3 (01) : 31 - 42
  • [6] Triterpenes and Triterpenoid Saponins from the Leaves of Ilex kudincha
    Zuo, Wen-Jian
    Dai, Hao-Fu
    Chen, Jing
    Chen, Hui-Qin
    Zhao, You-Xing
    Mei, Wen-Li
    Li, Xian
    Wang, Jin-Hui
    PLANTA MEDICA, 2011, 77 (16) : 1835 - 1840
  • [7] 2 NEW TRITERPENOID GLYCOSIDES FROM LEAVES OF ILEX-CHINENSIS SIMS
    INADA, A
    KOBAYASHI, M
    MURATA, H
    NAKANISHI, T
    CHEMICAL & PHARMACEUTICAL BULLETIN, 1987, 35 (02) : 841 - 845
  • [8] Triterpenoid saponins from the leaves of Ilex triflora Bl.
    Nga, Tran Thi
    Diep, Trinh Thi
    VIETNAM JOURNAL OF CHEMISTRY, 2025, 63 (01) : 54 - 60
  • [9] Three New E-Secoursane Triterpenoid Saponins from the Leaves of Ilex dunniana
    Zhang, Yue
    Li, Lu-Jun
    Zhang, Peng
    Pi, Hui-Fang
    Ruan, Han-Li
    Wu, Ji-Zhou
    HELVETICA CHIMICA ACTA, 2011, 94 (12) : 2207 - 2214
  • [10] Three new triterpenoid saponins from Ilex pubescens
    Li, Ling
    He, Yu-Xin
    Gou, Mei-Ling
    Dai, Chun
    JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2012, 14 (12) : 1169 - 1174
12345