The renin-angiotensin system: a possible new target for depression

被引：97

作者：

Vian, Joao ^{[1
,2
]}

Pereira, Ciria ^{[1
,2
]}

Chavarria, Victor ^{[3
]}

Kohler, Cristiano ^{[4
,5
]}

Stubbs, Brendon ^{[6
,7
,8
,9
]}

Quevedo, Joao ^{[10
,11
,12
,13
]}

King, Sung Wan ^{[18
]}

Carvalho, Andre F. ^{[4
,5
]}

Berk, Michael ^{[14
,15
,16
,17
]}

Fernandes, Brisa S. ^{[14
]}

机构：

[1] Ctr Hosp Lisboa Norte, Psychiat & Mental Hlth Dept, Lisbon, Portugal

[2] Univ Lisbon, Fac Med, Lisbon, Portugal

[3] PSM, Inst Neuropsiquiat & Adicc INAD, Barcelona, Spain

[4] Univ Fed Ceara, Translat Psychiat Res Grp, Fac Med, Fortaleza, Ceara, Brazil

[5] Univ Fed Ceara, Dept Clin Med, Fac Med, Fortaleza, Ceara, Brazil

[6] Anglia Ruskin Univ, Hlth Social Care & Educ, Chelmsford, Essex, England

[7] Kings Coll London, Inst Psychiat Psychol & Neurosci IoPPN, London, England

[8] Inst Clin Res & Educ Med IREM, Padua, Italy

[9] South London & Maudsley NHS Fdn Trust, Physiotherapy Dept, Denmark Hill, London SE5 8AZ, England

[10] Univ Texas Hlth Sci Ctr Houston UTHlth, Translat Psychiat Program, Dept Psychiat & Behav Sci, McGovern Med Sch, Houston, TX USA

[11] Univ Texas Hlth Sci Ctr Houston UTHlth, Ctr Excellence Mood Disorders, Dept Psychiat & Behav Sci, McGovern Med Sch, Houston, TX USA

[12] Univ Texas MD Anderson Canc Ctr UTHlth, Neurosci Grad Program, Houston, TX USA

[13] Univ Southern Santa Catarina UNESC, Lab Neurosci, Grad Program Hlth Sci, Hlth Sci Unit, Criciuma, SC, Brazil

[14] Deakin Univ, Univ Hosp Geelong, Sch Med, IMPACT Strateg Res Ctr,Barwon Hlth, Geelong, Vic, Australia

[15] Univ Melbourne, Dept Psychiat, Orygen Natl Ctr Excellence Youth Mental Hlth, Melbourne, Vic, Australia

[16] Univ Melbourne, Orygen Res Ctr, Melbourne, Vic, Australia

[17] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Melbourne, Vic, Australia

[18] Chonnam Natl Univ, Med Sch, Dept Psychiat, Gwangju, South Korea

来源：

BMC MEDICINE | 2017年 / 15卷

基金：

澳大利亚国家健康与医学研究理事会; 英国医学研究理事会;

关键词：

Depression; Psychiatry; Inflammation; Renin-angiotensin system; Angiotensin; ATR1; ATR2; Mas; Angiotensin receptor blockers; Angiotensin-converting enzyme inhibitors; CONVERTING-ENZYME GENE; QUALITY-OF-LIFE; ANXIETY-LIKE BEHAVIOR; TYPE-2 RECEPTOR AGONIST; FORCED SWIMMING TEST; C-REACTIVE PROTEIN; DOUBLE-BLIND; MAJOR DEPRESSION; NEUROTROPHIC FACTOR; N-ACETYLCYSTEINE;

D O I：

10.1186/s12916-017-0916-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin-angiotensin system. In the central nervous system, angiotensin II may be important in multiple pathways related to neurodevelopment and regulation of the stress response. Studies of drugs targeting the renin-angiotensin system have yielded promising results. Here, we review the potential beneficial effects of angiotensin blockers in depression and their mechanisms of action. Drugs blocking the angiotensin system have efficacy in several animal models of depression. While no randomised clinical trials were found, case reports and observational studies showed that angiotensin-converting enzyme inhibitors or angiotensin receptor blockers had positive effects on depression, whereas other antihypertensive agents did not. Drugs targeting the renin-angiotensin system act on inflammatory pathways implicated in depression. Both preclinical and clinical data suggest that these drugs possess antidepressant properties. In light of these results, angiotensin system-blocking agents offer new horizons in mood disorder treatment.

引用

页数：13

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