Palladium-Catalyzed α-Arylation of Arylketones at Low Catalyst Loadings

被引：27

作者：

Marelli, Enrico ^{[1
]}

Corpet, Martin ^{[1
]}

Davies, Sian R. ^{[1
]}

Nolan, Steven P. ^{[1
,2
]}

机构：

[1] Univ St Andrews, Sch Chem, EaStCHEM, St Andrews KY16 9ST, Fife, Scotland

[2] King Saud Univ, Coll Sci, Dept Chem, Riyadh 11451, Saudi Arabia

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2014年 / 20卷 / 52期

关键词：

catalysts; ketone arylation; monodentate ligands; NHC; palladium; HETEROCYCLIC CARBENE LIGANDS; CROSS-COUPLING REACTIONS; ADDRESSING CHALLENGES; REDUCTIVE ELIMINATION; SUZUKI-MIYAURA; ARYL HALIDES; KETONES; ACETONE; MONOARYLATION; COMPLEXES;

D O I：

10.1002/chem.201404900

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A general catalytic protocol for the alpha-arylation of aryl ketones has been developed. It involves the use of a preformed, bench-stable Pd-N-heterocyclic carbene pre-catalyst bearing IHept as an ancillary ligand, and allows the coupling of various functionalized coupling partners at very low catalyst loading. Careful choice of the solvent/base system was crucial to obtain optimum catalyst performance. The pre-catalyst was also successfully tested in the synthesis of an industrially relevant compound.

引用

页码：17272 / 17276

页数：5

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