Effect of substituents on diarylmethanes for antitubercular activity

被引：75
作者：
Panda, Gautam
Parai, Maloy Kumar
Das, Sajal Kumar
Shagufta
Sinha, Manish
Chaturvedi, Vinita
Srivastava, Anil K.
Manju, Y. S.
Gaikwad, Anil N.
Sinha, Sudhir
机构：
[1] Cent Drug Res Inst, Mat & Proc Chem Div, Lucknow 226001, Uttar Pradesh, India
[2] Cent Drug Res Inst, Div Microbiol, Lucknow 226001, Uttar Pradesh, India
[3] Cent Drug Res Inst, Drug Target Discovery & Dev Div, Lucknow 226001, Uttar Pradesh, India
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 03期
关键词：
antitubercular agents; diarylmethanes; phenanthrenes;
D O I：
10.1016/j.ejmech.2006.09.020
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Aminoalkyl derivatives of diarylmethanes were prepared using Grignard, Friedel-Crafts arylation and aminohydrochloride chain fort-nation reactions. These series of compounds were evaluated against Mycobacterium tuberculosis H37R nu, and showed the activity in the range of 6.25-925 mu g/mL. Effect of heteroaryl, anthracenyl and phenanthrene groups on diarylmethane pharmacophores for antitubercular activity is described. (c) 2006 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：410 / 419
页数：10
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