In vitro Cytotoxicity of Half-Sandwich Platinum Group Metal Complexes of a Cationic Alkylated Phosphaadamantane Ligand

被引：15

作者：

Burgoyne, Andrew R. ^{[1
]}

Kaschula, Catherine H. ^{[1
]}

Parker, M. Iqbal ^{[2
,3
]}

Smith, Gregory S. ^{[1
]}

机构：

[1] Univ Cape Town, Dept Chem, ZA-7701 Cape Town, South Africa

[2] Int Ctr Genet Engn & Biotechnol, ZA-7925 Cape Town, South Africa

[3] Univ Cape Town, Div Med Biochem, ZA-7701 Cape Town, South Africa

来源：

EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2016年 / 08期

基金：

新加坡国家研究基金会;

关键词：

Bioorganometallic chemistry; Half-sandwich complexes; Medicinal chemistry; Antitumor agents; DNA binding; 1,3,5-TRIAZA-7-PHOSPHAADAMANTANE PTA; ORGANOMETALLIC RUTHENIUM(II); ESOPHAGEAL CANCER; DNA INTERACTION; RAPTA-C; ANTICANCER; BINDING; RHODIUM; HYDROGENATION; NANOPARTICLES;

D O I：

10.1002/ejic.201501458

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Trinuclear and model mononuclear cationic monodentate Rh-III, Ir-III and Ru-II complexes with alkylated 1,3,5-triaza-7-phosphaadamantane (PTA) moieties have been prepared and characterized using NMR and IR spectroscopy, HR-ESI mass spectrometry and elemental analysis. The metals coordinate to the ligands via the phosphorus of the PTA, and this was confirmed by shifts in the P-31{H-1} NMR spectra. The cytotoxicities of all the compounds were investigated against the WHCO1 esophageal cancer cell line. The Ir-III mononuclear complex proved to be the most cytotoxic. Additionally, H-1 NMR model studies demonstrated its DNA binding ability while UV/Vis studies demonstrated the ability of the iridium mononuclear complex to interact with the double helix structure of Red Salmon testes DNA.

引用

页码：1267 / 1273

页数：7

共 58 条

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