The role of glutathione S-transferases (GSTs) in insecticide resistance in crop pests and disease vectors

被引：242

作者：

Pavlidi, Nena ^{[1
]}

Vontas, John ^{[2
,3
]}

Van Leeuwen, Thomas ^{[1
,4
]}

机构：

[1] Univ Amsterdam, IBED, Dept Evolutionary Biol, NL-1098 XH Amsterdam, Netherlands

[2] Fdn Res & Technol Hellas IMBB FOH, Inst Mol Biol & Biotechnol, Iraklion 70013, Greece

[3] Agr Univ Athens, Fac Crop Sci, Pesticide Sci Lab, GR-11855 Athens, Greece

[4] Univ Ghent, Fac Biosci Engn, Dept Plants & Crops, Lab Agrozool, B-9000 Ghent, Belgium

来源：

CURRENT OPINION IN INSECT SCIENCE | 2018年 / 27卷

关键词：

ORIENTAL FRUIT-FLY; MOLECULAR-MECHANISMS; EPSILON-CLASS; EXPRESSION; IDENTIFICATION; GENES; DETOXIFICATION; DEFENSE; CLONING; STRESS;

D O I：

10.1016/j.cois.2018.04.007

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Insecticide resistance seriously threatens efficient arthropod pest management. Arthropod glutathione S-transferases (GSTs) confer resistance via direct metabolism or sequestration of chemicals, but also indirectly by providing protection against oxidative stress induced by insecticide exposure. To date, GST activity has been associated with resistance to all main classes of insecticides. However, recent advances in genome and transcriptome sequencing, together with modern genetic, functional and biochemical techniques, facilitate the unraveling of specific GST-mediated resistance mechanisms. Recently, the role of a number of GSTs (BdGSTe2, BdGSTe4, AfGSTe2) has been validated by (reverse) genetic methods in vivo, while a number of GSTs (BmGSTu2, TuGSTd05, AfGSTe2) have now been shown to metabolize insecticides in vitro.

引用

页码：97 / 102

页数：6

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