Stimuli-Induced Core-Corona Inversion of Micelle of Poly(acrylic acid)-block-Poly(N-isopropylacrylamide) and Its Application in Drug Delivery

被引：47
作者：
Bastakoti, Bishnu Prasad [1 ]
Guragain, Sudhina [2 ]
Nakashima, Kenichi [2 ]
Yamauchi, Yusuke [1 ,3 ]
机构：
[1] Natl Inst Mat Sci, World Premier Int WPI Res Ctr Mat, Tsukuba, Ibaraki 3050044, Japan
[2] Saga Univ, Dept Chem, Fac Sci & Engn, Saga 8408502, Japan
[3] Waseda Univ, Fac Sci & Engn, Shinjuku Ku, Tokyo 1698555, Japan
来源：
MACROMOLECULAR CHEMISTRY AND PHYSICS | 2015年 / 216卷 / 03期
基金：
日本学术振兴会;
关键词：
block copolymers; core-corona inversion; drug carriers; polymeric micelles; schizophrenic micelles; SCHIZOPHRENIC DIBLOCK COPOLYMER; POLYMERIC MICELLES; BLOCK-COPOLYMER; CLOUD POINT; MOLECULAR-WEIGHT; SURFACTANTS; ACID); NANOSPHERES; MICELLIZATION; NANOPARTICLES;
D O I：
10.1002/macp.201400440
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Core-corona inversion of micelles of diblock copolymer poly(acrylic acid)-block-poly(N-isopropylacrylamide) (PAA-b-PNIPAM), has been successfully realized by switching either pH or temperature. The strong interaction of doxorubicin with the PAA block and the pH-sensitive drug release from the polymer make the system very useful as a controlled drug delivery system. The encapsulation of hydrophobic Nile Red molecules above the lower critical solution temperature of PNIPAM suggests that this polymer may be useful for removing hydrophobic pollutants.
引用
收藏
页码：287 / 291
页数：5
相关论文
共 43 条
[1]   Ultrathin poly(N-isopropylacrylamide) grafted layer on polystyrene surfaces for cell adhesion/detachment control [J].
Akiyama, Y ;
Kikuchi, A ;
Yamato, M ;
Okano, T .
LANGMUIR, 2004, 20 (13) :5506-5511
[2]   pH-responsive polymeric micelles with core-shell-corona architectures as intracellular anti-cancer drug carriers [J].
Bastakoti, Bishnu Prasad ;
Liao, Shih-Hsiang ;
Inoue, Masamichi ;
Yusa, Shin-Ichi ;
Imura, Masataka ;
Nakashima, Kenichi ;
Wu, Kevin C-W ;
Yamauchi, Yusuke .
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 2013, 14 (04)
[3]   Inorganic-Organic Hybrid Nanoparticles with Biocompatible Calcium Phosphate Thin Shells for Fluorescence Enhancement [J].
Bastakoti, Bishnu Prasad ;
Hsu, Yin-Chu ;
Liao, Shih-Hsiang ;
Wu, Kevin C. -W. ;
Inoue, Masamichi ;
Yusa, Shin-ichi ;
Nakashima, Kenichi ;
Yamauchi, Yusuke .
CHEMISTRY-AN ASIAN JOURNAL, 2013, 8 (06) :1301-1305
[4]   Multifunctional Core-Shell-Corona-Type Polymeric Micelles for Anticancer Drug-Delivery and Imaging [J].
Bastakoti, Bishnu Prasad ;
Wu, Kevin C. -W. ;
Inoue, Masamichi ;
Yusa, Shin-ichi ;
Nakashima, Kenichi ;
Yamauchi, Yusuke .
CHEMISTRY-A EUROPEAN JOURNAL, 2013, 19 (15) :4812-4817
[5]   A block copolymer micelle template for synthesis of hollow calcium phosphate nanospheres with excellent biocompatibility [J].
Bastakoti, Bishnu Prasad ;
Inuoe, Masamichi ;
Yusa, Shin-ichi ;
Liao, Shih-Hsiang ;
Wu, Kevin C. -W. ;
Nakashima, Kenichi ;
Yamauchi, Yusuke .
CHEMICAL COMMUNICATIONS, 2012, 48 (52) :6532-6534
[6]   Synthesis of hollow BaSO4 nanospheres templated by core-shell-corona type polymeric micelles [J].
Bastakoti, Bishnu Prasad ;
Guragain, Sudhina ;
Yokoyama, Yuuichi ;
Yusa, Shin-ichi ;
Nakashima, Kenichi .
NEW JOURNAL OF CHEMISTRY, 2012, 36 (01) :125-129
[7]   Synthesis of Hollow CaCO3 Nanospheres Templated by Micelles of Poly(styrene-b-acrylic acid-b-ethylene glycol) in Aqueous Solutions [J].
Bastakoti, Bishnu Prasad ;
Guragain, Sudhina ;
Yokoyama, Yuuichi ;
Yusa, Shin-ichi ;
Nakashima, Kenichi .
LANGMUIR, 2011, 27 (01) :379-384
[8]   The Effect of Hofmeister Salts on the LCST Transition of Poly(2-oxazoline)s with Varying Hydrophilicity [J].
Bloksma, Meta M. ;
Bakker, Daniel J. ;
Weber, Christine ;
Hoogenboom, Richard ;
Schubert, Ulrich S. .
MACROMOLECULAR RAPID COMMUNICATIONS, 2010, 31 (08) :724-728
[9]   Supramolecular Nanodevices: From Design Validation to Theranostic Nanomedicine [J].
Cabral, Horacio ;
Nishiyama, Nobuhiro ;
Kataoka, Kazunori .
ACCOUNTS OF CHEMICAL RESEARCH, 2011, 44 (10) :999-1008
[10]   Tellurium-Containing Polymer Micelles: Competitive-Ligand-Regulated Coordination Responsive Systems [J].
Cao, Wei ;
Gu, Yuwei ;
Meineck, Myriam ;
Li, Tianyu ;
Xu, Huaping .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2014, 136 (13) :5132-5137
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