When worlds collide: Th17 and Treg cells in cancer and autoimmunity

被引：402

作者：

Knochelmann, Hannah M. ^{[1
,2
]}

Dwyer, Connor J. ^{[1
,2
]}

Bailey, Stefanie R. ^{[1
,2
]}

Amaya, Sierra M. ^{[1
,2
]}

Elston, Dirk M. ^{[2
]}

Mazza-McCrann, Joni M. ^{[2
]}

Paulos, Chrystal M. ^{[1
,2
]}

机构：

[1] Med Univ South Carolina, Dept Microbiol & Immunol, Charleston, SC 29425 USA

[2] Med Univ South Carolina, Dept Dermatol & Dermatol Surg, Charleston, SC 29425 USA

来源：

CELLULAR & MOLECULAR IMMUNOLOGY | 2018年 / 15卷 / 05期

关键词：

autoimmunity; cancer; immunotherapy; Th17; Treg; REGULATORY T-CELLS; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; IMMUNE CHECKPOINT BLOCKADE; TRANSCRIPTION FACTOR; TGF-BETA; METASTATIC MELANOMA; IFN-GAMMA; MULTIPLE-SCLEROSIS; CUTTING EDGE; NEUTROPHIL RECRUITMENT;

D O I：

10.1038/s41423-018-0004-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The balance between Th17 cells and regulatory T cells (Tregs) has emerged as a prominent factor in regulating autoimmunity and cancer. Th17 cells are vital for host defense against pathogens but have also been implicated in causing autoimmune disorders and cancer, though their role in carcinogenesis is less well understood. Tregs are required for self-tolerance and defense against autoimmunity and often correlate with cancer progression. This review addresses the importance of a functional homeostasis between these two subsets in health and the consequences of its disruption when these forces collide in disease. Importantly, we discuss the ability of Th17 cells to mediate cancer regression in immunotherapy, including adoptive transfer and checkpoint blockade therapy, and the therapeutic possibilities of purposefully offsetting the Th17/Treg balance to treat patients with cancer as well as those with autoimmune diseases.

引用

页码：458 / 469

页数：12

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