Role of adipokines in complications related to obesity. A review

被引：120
作者：
Gnacinska, M. [2 ]
Malgorzewicz, S. [1 ]
Stojek, M. [3 ]
Lysiak-Szydlowska, W. [2 ]
Sworczak, K. [2 ]
机构：
[1] Med Univ Gdansk, Dept Clin Nutr, PL-80210 Gdansk, Poland
[2] Med Univ Gdansk, Dept Endocrinol & Internal Med, PL-80210 Gdansk, Poland
[3] Med Univ Gdansk, Dept Gastroenterol, PL-80210 Gdansk, Poland
来源：
ADVANCES IN MEDICAL SCIENCES | 2009年 / 54卷 / 02期
关键词：
adipokines; obesity; metabolic complications; ADIPOSE-TISSUE; INSULIN-RESISTANCE; METABOLIC SYNDROME; ADIPONECTIN; LEPTIN; ENDOCRINE; ADIPOCYTOKINES; INFLAMMATION; BIOLOGY; PROTEIN;
D O I：
10.2478/v10039-009-0035-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Worldwide, the prevalence of overweight and obesity and associated complications is increasing. Cardiovascular complications are the most important factor determining survival and influencing clinical management. However, obesity is also associated with an increased risk of metabolic syndrome, type 2 diabetes, cancer and other diseases. The development of complications depends on the amount of body fat and its endocrine function. The hormones (leptin, adiponectin, resistin) and cytokines (TNF alpha, IL-6, PAI-1) produced by the adipose tissue are the link between obesity and obesity-related complications. The present article discusses the structure, function and clinical significance of adipokines.
引用
收藏
页码：150 / 157
页数：8
相关论文
共 66 条
[1]   An update on the biology and physiology of resistin [J].
Adeghate, E .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (19-20) :2485-2496
[2]   Adipose tissue as an endocrine organ [J].
Ahima, RS ;
Flier, JS .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2000, 11 (08) :327-332
[3]   Role of leptin in glucose metabolism in type 2 diabetes [J].
Al-Daghri, N ;
Bartlett, WA ;
Jones, AF ;
Kumar, S .
DIABETES OBESITY & METABOLISM, 2002, 4 (03) :147-155
[4]  
BOGDANSKI P, 2002, DIABETOLOGIA DOSWIAD, V2, P449
[5]   Obese (ob) gene defects are rare in human obesity [J].
Carlsson, B ;
Lindell, K ;
Gabrielsson, B ;
Karlsson, C ;
Bjarnason, R ;
Westphal, O ;
Karlsson, U ;
Sjostrom, L ;
Carlsson, LMS .
OBESITY RESEARCH, 1997, 5 (01) :30-35
[6]   Direct metabolic regulation in skeletal muscle and fat tissue by leptin: implications for glucose and fatty acids homeostasis [J].
Ceddia, RB .
INTERNATIONAL JOURNAL OF OBESITY, 2005, 29 (10) :1175-1183
[7]   Current treatment options for the metabolic syndrome [J].
Deedwania P.C. ;
Volkova N. .
Current Treatment Options in Cardiovascular Medicine, 2005, 7 (1) :61-74
[8]  
Dieterle C, 2006, INTERNIST, V47, P141, DOI 10.1007/s00108-005-1552-0
[9]  
DRZEWOSKI J, 2005, PODRECZNY LEKSYKON D, V63
[10]   The role of adipokines as regulators of skeletal muscle fatty acid metabolism and insulin sensitivity [J].
Dyck, DJ ;
Heigenhauser, GJF ;
Bruce, CR .
ACTA PHYSIOLOGICA, 2006, 186 (01) :5-16
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