Molecular psychiatry of zebrafish

被引：155
作者：
Stewart, A. M. [1 ,2 ]
Ullmann, J. F. P. [2 ,3 ]
Norton, W. H. J. [2 ,4 ]
Parker, M. O. [5 ]
Brennan, C. H. [5 ]
Gerlai, R. [6 ]
Kalueff, A. V. [1 ,2 ,7 ]
机构：
[1] ZENEREI Inst, Slidell, LA 70458 USA
[2] Int Zebrafish Neurosci Res Consortium, Slidell, LA USA
[3] Univ Queensland, Ctr Adv Imaging, Brisbane, Qld, Australia
[4] Univ Leicester, Coll Med Biol Sci & Psychiat, Dept Biol, Leicester, Leics, England
[5] Queen Mary Univ London, Sch Biol & Chem Sci, London, England
[6] Univ Toronto, Dept Psychiat, Mississauga, ON L5L 1C6, Canada
[7] Guangdong Ocean Univ, Coll Food Sci & Technol, Res Inst Marine Drugs & Nutr, Zhanjiang, Guangdong, Peoples R China
来源：
MOLECULAR PSYCHIATRY | 2015年 / 20卷 / 01期
基金：
英国国家替代、减少和改良动物研究中心; 美国国家卫生研究院; 英国医学研究理事会; 英国生物技术与生命科学研究理事会;
关键词：
REACTION-TIME-TASK; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; POSTTRAUMATIC-STRESS-DISORDER; GENE-EXPRESSION CHANGES; DANIO-RERIO; ADULT ZEBRAFISH; ALCOHOL EXPOSURE; RECEPTOR GENES; CATECHOLAMINERGIC SYSTEMS;
D O I：
10.1038/mp.2014.128
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Due to their well-characterized neural development and high genetic homology to mammals, zebrafish (Danio rerio) have emerged as a powerful model organism in the field of biological psychiatry. Here, we discuss the molecular psychiatry of zebrafish, and its implications for translational neuroscience research and modeling central nervous system (CNS) disorders. In particular, we outline recent genetic and technological developments allowing for in vivo examinations, high-throughput screening and whole-brain analyses in larval and adult zebrafish. We also summarize the application of these molecular techniques to the understanding of neuropsychiatric disease, outlining the potential of zebrafish for modeling complex brain disorders, including attention-deficit/hyperactivity disorder (ADHD), aggression, post-traumatic stress and substance abuse. Critically evaluating the advantages and limitations of larval and adult fish tests, we suggest that zebrafish models become a rapidly emerging new field in modern molecular psychiatry research.
引用
收藏
页码：2 / 17
页数：16
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