Synthesis of a Parkinson's Disease Treatment Drug, the R,R-Tartrate Salt of R-Rasagiline: A Three Week Introductory Organic Chemistry Lab Sequence

被引：7

作者：

Aguilar, Noberto ^{[1
]}

Garcia, Billy ^{[1
]}

Cunningham, Mark ^{[2
]}

David, Samuel ^{[1
]}

机构：

[1] Univ Texas Permian Basin, Dept Chem, 4901 East Univ, Odessa, TX 79762 USA

[2] Atlanta Metropolitan Coll, 1630 Metropolitan Pkwy Southwest, Atlanta, GA 30310 USA

来源：

JOURNAL OF CHEMICAL EDUCATION | 2016年 / 93卷 / 05期

关键词：

Second-Year Undergraduate; Upper-Division Undergraduate; Organic Chemistry; Chirality/Optical Activity; Synthesis; Diastereomers; Drugs/Pharmaceuticals; Asymmetric Synthesis; Hands-On Learning/Manipulatives; MONOAMINE-OXIDASE-B; MULTISTEP SYNTHESIS; INHIBITOR; DERIVATIVES; CELLS;

D O I：

10.1021/acs.jchemed.5b00357

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A synthesis of the R,R-tartrate salt of the popular anti-Parkinson's drug R-rasagiline (Azilect) was adapted to introduce the organic laboratory student to a medically relevant synthesis. It makes use of concepts found in the undergraduate organic chemistry curriculum, appropriately fits into three approximately 4 h lab periods, and utilizes readily available equipment and inexpensive commercially available chemicals.

引用

页码：937 / 940

页数：4

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