Increased zinc finger protein zFOC1 transcripts in gastric cancer compared with normal gastric tissue

被引：4
作者：
Stephen, RL
Crabtree, JE
Yoshimura, T
Clayton, CL
Dixon, MF
Robinson, PA
机构：
[1] St James Univ Hosp, Mol Med Unit, Leeds LS9 7TF, W Yorkshire, England
[2] Glaxo SmithKline Res & Dev, Genom Unit, Stevenage SG1 2NY, Herts, England
来源：
JOURNAL OF CLINICAL PATHOLOGY-MOLECULAR PATHOLOGY | 2003年 / 56卷 / 03期
关键词：
D O I：
10.1136/mp.56.3.167
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Background: Screening of cDNA arrays of the IMAGE library identified human zFOC1 as a differentially expressed cDNA that was upregulated in KATO III gastric cancer cells following stimulation with the gastric pathogen Helicobacter pylori. Aims: To determine the expression of zFOC1 in gastric mucosa with and without H pylori infection and in patients with gastric cancer. Results: zFOC1 is localised on chromosome 12q24.3 and encodes a zinc finger protein. Expression studies in human H pylori infected and uninfected gastric biopsies, gastric tumours, and gastric cancer cell lines revealed that zFOC1 gene transcripts are significantly higher in gastric cancer than in non-cancerous gastric tissues. Conclusions: The zFOC1 gene appears to be a tumour marker associated with gastric cancer.
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收藏
页码：167 / 171
页数：5
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