The clinical observation of verapamil in combination with interventional chemotherapy in advanced gastric cancer

被引：3

作者：

Fan, G-F ^{[1
]}

Pan, J-J ^{[2
]}

Fan, P-S ^{[1
]}

Zhang, T-Y ^{[1
]}

Liu, Y-B ^{[1
]}

Huang, J. ^{[1
]}

Weng, C-T ^{[1
]}

Liu, M. ^{[1
]}

Duan, Q-H ^{[1
]}

Wu, Y. ^{[1
]}

Tang, L-L ^{[1
]}

Yang, G-H ^{[1
]}

Dai, H-B ^{[3
]}

Zhu, Z-Q ^{[3
]}

机构：

[1] Univ Sci & Technol China West, Dept Med Oncol, Affiliated Hosp 1, Hefei, Anhui, Peoples R China

[2] Nanjing Med Univ, Affiliated Changzhou Peoples Hosp 2, Dept Oncol, Changzhou 2, Jiangsu, Peoples R China

[3] Univ Sci & Technol China, Affiliated Hosp 1, Dept Gen Surg, Hefei, Anhui, Peoples R China

来源：

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES | 2018年 / 22卷 / 17期

基金：

中国国家自然科学基金;

关键词：

Verapamil; Chemotherapy drugs; Interventional chemotherapy; Gastric cancer; INFUSION CHEMOTHERAPY; CISPLATIN RESISTANCE; DRUG-RESISTANCE; EXPRESSION; CELLS;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

OBJECTIVE: We analyzed the clinical observations of target arterial infusion of verapamil combined with chemotherapy as therapy for advanced gastric cancer. PATIENTS AND METHODS: From March 2012 to December 2015, a total of 63 patients with advanced gastric cancer were admitted to our department. The target artery in the control group was perfused with chemotherapy drugs only, and the target artery in the therapy group was injected with verapamil combined with chemotherapy drugs. RESULTS: The therapeutic effect of the therapy group was significantly better than that of the control group in the primary foci of gastric cancer. Liver metastatic lesions: 11 patients in the control group had liver metastases and 25 patients in the therapy group had liver metastases. The effective rate (CR+PR) of the therapy group was significantly better than the control group. Clinical benefit evaluation: in the therapy group of 43 cases, 40 cases presented positive clinical benefit and 38 cases positive clinical weight in KFS scoring system; the clinical benefit of the therapy group was significantly better than control group. Survival analysis: the disease progression-free rate and survival rate of the therapy group were 12 months and 24 months, which were higher than those in the control group. The median PFS and median OS were also significantly longer than those in the control group (p<0.01). In the therapy group, adverse effects of chemotherapy in 43 patients were relieved in a short time. CONCLUSIONS: Target arterial infusion of verapamil combined with chemotherapy drugs for advanced gastric cancer can significantly improve the efficacy of chemotherapy drugs and prolong the survival of patients.

引用

页码：5508 / 5518

页数：11

共 28 条

[1]

Aoyagi Keishiro, 2004, Gan To Kagaku Ryoho, V31, P1678

[2] Prognostic factors influencing the survival of patients with carcinoma of the gastric cardia receiving preoperative interventional embolization chemotherapy [J].

Cao, Hai-Li ;

Jin, Shu-Qiang ;

Wang, Kai-Bing ;

Bai, Bin .

ONCOTARGET, 2017, 8 (45) :79567-79575

[3] Computed tomography perfusion in evaluating the therapeutic effect of transarterial chemoembolization for hepatocellular carcinoma [J].

Chen, Guang ;

Ma, Da-Qing ;

He, Wen ;

Zhang, Bao-Feng ;

Zhao, Li-Qin .

WORLD JOURNAL OF GASTROENTEROLOGY, 2008, 14 (37) :5738-5743

[4]

Chen HB, 2017, EUR REV MED PHARMACO, V21, P1753

[5]

Chen Y, 2017, EUR REV MED PHARMACO, V21, P2617

[6] Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer [J].

Cheruvu, Praveena ;

Metcalfe, Su K. ;

Metcalfe, Justin ;

Chen, Yuhchyau ;

Okunieff, Paul ;

Milano, Michael T. .

RADIATION ONCOLOGY, 2011, 6

[7] Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer [J].

de Gramont, A ;

Figer, A ;

Seymour, M ;

Homerin, M ;

Hmissi, A ;

Cassidy, J ;

Boni, C ;

Cortes-Funes, H ;

Cervantes, A ;

Freyer, G ;

Papamichael, D ;

Le Bail, N ;

Louvet, C ;

Hendler, D ;

de Braud, F ;

Wilson, C ;

Morvan, F ;

Bonetti, A .

JOURNAL OF CLINICAL ONCOLOGY, 2000, 18 (16) :2938-2947

[8] Docetaxel in advanced gastric cancer - Review of the main clinical trials [J].

Di Cosimo, S ;

Ferretti, G ;

Fazio, N ;

Silvestris, N ;

Carlini, P ;

Alimonti, A ;

Gelibter, A ;

Felici, A ;

Papaldo, P ;

Cognetti, F .

ACTA ONCOLOGICA, 2003, 42 (07) :693-700

[9] Effect of MDR modulators verapamil and promethazine on gene expression levels of MDR1 and MRP1 in doxorubicin-resistant MCF-7 cells [J].

Donmez, Yaprak ;

Akhmetova, Laila ;

Iseri, Ozlem Darcansoy ;

Kars, Meltem Demirel ;

Gunduz, Ufuk .

CANCER CHEMOTHERAPY AND PHARMACOLOGY, 2011, 67 (04) :823-828

[10] Basic and Clinical Research on the Therapeutic Effect of Intervention in Primary Liver Cancer by Targeted Intra-Arterial Verapamil Infusion [J].

Fan Pingsheng ;

Zhang Tengyue ;

Huang Qiang ;

Wei Qiang ;

Sun Xin ;

Qian Liting .

CELL BIOCHEMISTRY AND BIOPHYSICS, 2012, 62 (01) :59-67

← 1 2 3 →