Antibody response after a third dose mRNA-1273 vaccine among vaccinated healthcare workers with two doses of inactivated SARS-CoV-2 vaccine

被引：13
作者：
Cucunawangsih, Cucunawangsih [1 ]
Wijaya, Ratna Sari [1 ]
Lugito, Nata Pratama Hardjo [2 ]
Suriapranata, Ivet [3 ,4 ]
机构：
[1] Pelita Harapan Univ, Fac Med, Dept Microbiol, Tangerang, Indonesia
[2] Pelita Harapan Univ, Fac Med, Dept Internal Med, Tangerang, Indonesia
[3] Pelita Harapan Univ, Mochtar Riady Inst Nanotechnol, Div Immunol, Tangerang, Indonesia
[4] Pelita Harapan Univ, Med Sci Grp, Tangerang, Indonesia
来源：
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2022年 / 118卷
关键词：
COVID-19; vaccination; booster; healthcare workers;
D O I：
10.1016/j.ijid.2022.02.036
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Background: Health care workers (HCWs), a high-risk group for contracting COVID-19 disease, are being prioritized to receive COVID-19 vaccination. A third dose messenger RNA (mRNA) vaccine, mRNA-1273 (Moderna), after 2 doses of inactivated vaccine (CoronaVac), has been used to increase the level of protection against SARS-CoV-2 among Indonesian HCWs. However, data regarding antibody response after mRNA-1273 booster dose are limited. Objective: To evaluate the receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein (anti-S) titers induced by the third mRNA-1273 vaccine among fully vaccinated HCWs with CoronaVac. Results: A total of 90 HCWs with no history of SARS-CoV-2 infection and who had received the third dose of vaccination were included in this study. The mRNA-1273 vaccine booster was administered 6 months after completing primary vaccination with CoronaVac. After the third dose, the anti-S antibodies level significantly increased, from a median of 41.7 U/mL (interquartile range [IQR], 22.4-92.5) to 28 394 U/mL (IQR, 20 837-41 646) (p <0.0001). After the third dose, seropositivity with the anti-S antibodies level >210 U/mL was observed in all HCWs. Age was negatively associated with the anti-S antibodies level after the mRNA-1273 booster. Conclusion: The heterologous prime booster with CoronaVac and mRNA-1273 vaccine booster elicit a pronounced antibody response against SARS-CoV-2 infection. (C) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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收藏
页码：116 / 118
页数：3
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