Cereboost™, an American ginseng extract, improves cognitive function via up-regulation of choline acetyltransferase expression and neuroprotection

被引：39

作者：

Shin, Kyungha ^{[1
]}

Guo, Haiyu ^{[1
]}

Cha, Yeseul ^{[1
]}

Ban, Young-Hwan ^{[1
]}

Seo, Da Woom ^{[1
]}

Choi, Youngjin ^{[1
]}

Kim, Tae-Su ^{[2
]}

Lee, Sung-Pyo ^{[2
]}

Kim, Jong-Choon ^{[3
]}

Choi, Ehn-Kyoung ^{[1
]}

Yon, Jung-Min ^{[1
]}

Kim, Yun-Bae ^{[1
]}

机构：

[1] Chungbuk Natl Univ, Coll Vet Med, 1 Chungdaero Gaesin Dong, Cheongju 28644, Chungbuk, South Korea

[2] Anydoctor Healthcare Co Ltd, Cheonan 31066, Chungnam, South Korea

[3] Chonnam Natl Univ, Coll Vet Med, Gwangju 61186, South Korea

来源：

REGULATORY TOXICOLOGY AND PHARMACOLOGY | 2016年 / 78卷

基金：

新加坡国家研究基金会;

关键词：

Amyloid-beta peptide; Cognitive function; Cereboost (TM); American ginseng (Panax quinquefolius); Choline acetyltransferase; Neuroprotection; AMYLOID-BETA; ALZHEIMERS-DISEASE; MEMORY IMPAIRMENT; BLACK GINSENG; A-BETA; GINSENOSIDES; DYSFUNCTION; PEPTIDE; RB1; RG1;

D O I：

10.1016/j.yrtph.2016.04.006

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

In Alzheimer disease (AD), amyloid-beta (A beta) peptides induce the degeneration of presynaptic cholinergic system, in which decreased activity of enzyme choline acetyltransferase (ChAT) responsible for acetylcholine synthesis is observed. Cereboost (TM), an extract of American ginseng extract, contains a high concentration of Rbl ginsenoside which is a well-known ingredient improving human cognitive function. We investigated the effects of Cereboost (TM) on learning and memory, function of mice challenged with an A beta(1-42) peptide and the underlying mechanisms in vitro. Cereboost (TM) protected against A beta(1-42) induced cytotoxicity in F3.ChAT stem cells, and enhanced the ChAT gene expression. A beta(1-42) injection into the mouse brain impaired the cognitive function, which was recovered by oral administration of Cereboost (TM). In addition, Cereboost (TM) restored brain microtubule-associated protein 2 and synaptophysin as well as acetylcholine concentration. The results demonstrate that Cereboost (TM) administration recovered the cognitive function of AD model animals by enhancing acetylcholine level via ChAT gene expression and neuroprotection. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：53 / 58

页数：6

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