Characterization of HIV-1 subtypes and transmitted drug resistance among treatment-naive HIV-infected individuals in Zhejiang, China, 2014-2017

被引：27

作者：

Xu, Yufan ^{[1
]}

Peng, Xiaorong ^{[1
]}

Peng, Xiuming ^{[1
]}

Ji, Shujing ^{[1
]}

Chen, Bin ^{[1
]}

Wang, Liyan ^{[1
]}

Lu, Xiangyun ^{[1
]}

Xie, Tiansheng ^{[1
]}

Sun, Tao ^{[1
]}

Wang, Hui ^{[2
]}

Wu, Nanping ^{[1
]}

机构：

[1] Zhejiang Univ, State Key Lab Diag & Treatment Infect Dis, Collaborat Innovat Ctr Diag & Treatment Infect Di, Affiliated Hosp 1,Sch Med, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China

[2] Third Peoples Hosp Shenzhen, Shenzhen 518112, Peoples R China

来源：

ARCHIVES OF VIROLOGY | 2018年 / 163卷 / 08期

基金：

国家高技术研究发展计划(863计划);

关键词：

ANTIRETROVIRAL THERAPY; TRENDS;

D O I：

10.1007/s00705-018-3839-1

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In recent years, transmitted drug resistance (TDR) has adversely impacted upon first-line therapy for HIV-infected individuals. To understand the current subtype distribution and TDR level in Zhejiang, China we performed phylogenetic analysis and genotypic drug resistance testing of treatment-naive HIV-infected individuals. A total of 153 HIV-1 Pol genes were successfully amplified. The distribution of HIV-1 genotypes was as follows: CRF01_AE (43.8%); CRF07_BC (37.9%); subtype B/B' (7.2%); CRF08_BC (5.2%); and others (5.9%). Drug resistance analysis demonstrated that 11.1% of isolates contained at least one NRTI or NNRTI resistance-associated mutations while 2.0% were identified to be resistant to PIs. These findings enhance our understanding of the genetic diversity of HIV-1 strains circulating in Zhejiang and provide some guidelines for HIV initial treatment therapy.

引用

页码：2233 / 2237

页数：5

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