Monodisperse magnetic nanoparticles for biomedical applications

被引：151

作者：

Xu, Chenjie ^{[1
]}

Sun, Shouheng ^{[1
]}

机构：

[1] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

POLYMER INTERNATIONAL | 2007年 / 56卷 / 07期

关键词：

magnetic nanciparticles; chemical synthesis; surface functionalization; biomedical applications; IRON-OXIDE NANOPARTICLES; FEPT NANOPARTICLES; SUPERPARAMAGNETIC NANOPARTICLES; NANOCRYSTALS; SIZE; CANCER; SHELL; STABILIZATION; SUPERLATTICES; DIAGNOSIS;

D O I：

10.1002/pi.2251

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Magnetic nanoparticles that are superparamagnetic with high saturation moment have great potential for biomedical applications. Solution-phase syntheses have recently been applied to make various kinds of monodisperse magnetic nanoparticles with standard deviation in diameter of less than 10%. However, the surface of these nanoparticles is coated with a layer of hydrocarbon molecules due to the use of lipid-like carboxylic acid and amine in the syntheses. Surface functionalization leads to the formation of water-soluble nanoparticles that can be further modified with various biomolecules. Such functionalization has brought about several series of monodisperse magnetic nanoparticle systems that have shown promising applications in protein or DNA separation, detection and magnetic resonance imaging contrast enhancement. The goal of this mini review is to summarize the recent progress in the synthesis and surface modification of monodisperse magnetic nanoparticles and their applications in biomedicine. (C) 2007 Society of Chemical Industry.

引用

页码：821 / 826

页数：6

共 62 条

[31] Superparamagnetic nanoparticles for biomedical applications:: Possibilities and limitations of a new drug delivery system [J].