Monodisperse magnetic nanoparticles for biomedical applications

被引：151
作者：
Xu, Chenjie [1 ]
Sun, Shouheng [1 ]
机构：
[1] Brown Univ, Dept Chem, Providence, RI 02912 USA
来源：
POLYMER INTERNATIONAL | 2007年 / 56卷 / 07期
关键词：
magnetic nanciparticles; chemical synthesis; surface functionalization; biomedical applications; IRON-OXIDE NANOPARTICLES; FEPT NANOPARTICLES; SUPERPARAMAGNETIC NANOPARTICLES; NANOCRYSTALS; SIZE; CANCER; SHELL; STABILIZATION; SUPERLATTICES; DIAGNOSIS;
D O I：
10.1002/pi.2251
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Magnetic nanoparticles that are superparamagnetic with high saturation moment have great potential for biomedical applications. Solution-phase syntheses have recently been applied to make various kinds of monodisperse magnetic nanoparticles with standard deviation in diameter of less than 10%. However, the surface of these nanoparticles is coated with a layer of hydrocarbon molecules due to the use of lipid-like carboxylic acid and amine in the syntheses. Surface functionalization leads to the formation of water-soluble nanoparticles that can be further modified with various biomolecules. Such functionalization has brought about several series of monodisperse magnetic nanoparticle systems that have shown promising applications in protein or DNA separation, detection and magnetic resonance imaging contrast enhancement. The goal of this mini review is to summarize the recent progress in the synthesis and surface modification of monodisperse magnetic nanoparticles and their applications in biomedicine. (C) 2007 Society of Chemical Industry.
引用
收藏
页码：821 / 826
页数：6
相关论文
共 62 条
[21]   Nanoscale size effect of magnetic nanocrystals and their utilization for cancer diagnosis via magnetic resonance imaging [J].
Jun, YW ;
Huh, YM ;
Choi, JS ;
Lee, JH ;
Song, HT ;
Kim, S ;
Yoon, S ;
Kim, KS ;
Shin, JS ;
Suh, JS ;
Cheon, J .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2005, 127 (16) :5732-5733
[22]   Magnetic iron oxide nanoparticles for biorecognition: Evaluation of surface coverage and activity [J].
Koh, I ;
Wang, X ;
Varughese, B ;
Isaacs, L ;
Ehrman, SH ;
English, DS .
JOURNAL OF PHYSICAL CHEMISTRY B, 2006, 110 (04) :1553-1558
[23]   Mechanistic studies on the conversion of dicobalt octacarbonyl into colloidal cobalt nanoparticles [J].
Lagunas, A ;
Jimeno, C ;
Font, D ;
Solà, L ;
Pericàs, MA .
LANGMUIR, 2006, 22 (08) :3823-3829
[24]   Size and interface effects on ferromagnetic and antiferromagnetic transition temperatures [J].
Lang, X. Y. ;
Zheng, W. T. ;
Jiang, Q. .
PHYSICAL REVIEW B, 2006, 73 (22)
[25]   Antibiofouling polymer-coated superparamagnetic iron oxide nanoparticles as potential magnetic resonance contrast agents for in vivo cancer imaging [J].
Lee, Haerim ;
Lee, Eunhye ;
Kim, Do Kyung ;
Jang, Nam Kyu ;
Jeong, Yong Yeon ;
Jon, Sangyong .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (22) :7383-7389
[26]   Spin valve biosensors: Signal dependence on nanoparticle position [J].
Li, Guanxiong ;
Sun, Shouheng ;
Wang, Shan X. .
JOURNAL OF APPLIED PHYSICS, 2006, 99 (08)
[27]   Spin valve sensors for ultrasensitive detection of superparamagnetic nanoparticles for biological applications [J].
Li, GX ;
Sun, SH ;
Wilson, RJ ;
White, RL ;
Pourmand, N ;
Wang, SX .
SENSORS AND ACTUATORS A-PHYSICAL, 2006, 126 (01) :98-106
[28]   Magnetic carriers of iron nanoparticles coated with a functional polymer for high throughput bioscreening [J].
Maeda, M. ;
Kuroda, C. S. ;
Shimura, T. ;
Tada, M. ;
Abe, M. ;
Yamamuro, S. ;
Sumiyama, K. ;
Handa, H. .
JOURNAL OF APPLIED PHYSICS, 2006, 99 (08)
[29]   Quantum dot bioconjugates for imaging, labelling and sensing [J].
Medintz, IL ;
Uyeda, HT ;
Goldman, ER ;
Mattoussi, H .
NATURE MATERIALS, 2005, 4 (06) :435-446
[30]   Quantum dots for live cells, in vivo imaging, and diagnostics [J].
Michalet, X ;
Pinaud, FF ;
Bentolila, LA ;
Tsay, JM ;
Doose, S ;
Li, JJ ;
Sundaresan, G ;
Wu, AM ;
Gambhir, SS ;
Weiss, S .
SCIENCE, 2005, 307 (5709) :538-544
1234567