A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units

被引：39
作者：
Cui, Peng-Fei [1 ,2 ,3 ,4 ]
Zhuang, Wan-Ru [1 ]
Hu, Xi [5 ]
Xing, Lei [1 ,2 ,3 ,4 ]
Yu, Ru-Yi [1 ]
Qiao, Jian-Bin [1 ]
He, Yu-Jing [1 ]
Li, Fangyuan [5 ]
Ling, Daishun [5 ]
Jiang, Hu-Lin [1 ,2 ,3 ,4 ]
机构：
[1] China Pharmaceut Univ, Dept Pharmaceut, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, Nanjing 210009, Jiangsu, Peoples R China
[3] China Pharmaceut Univ, Jiangsu Key Lab Drug Discovery Metab Dis, Nanjing 210009, Jiangsu, Peoples R China
[4] China Pharmaceut Univ, Jiangsu Key Lab Drugaabil Biopharmaceut, Nanjing 210009, Jiangsu, Peoples R China
[5] Zhejiang Univ, Coll Pharmaceut Sci, State Zhejiang Prov Key Lab Anticanc Drug Res, Hangzhou 310058, Zhejiang, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2018年 / 54卷 / 59期
基金：
中国国家自然科学基金;
关键词：
ARGININE-ASSISTED SOLUBILIZATION; MICROSCALE THERMOPHORESIS; MULTIDRUG-RESISTANCE; CARBON NANOTUBES; BREAST-CANCER; NANOPARTICLES; MICELLES; VEHICLES; RELEASE; NANOSTRUCTURES;
D O I：
10.1039/c8cc04363a
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A highly hydrophilic polymer equipped with guanidinium groups was used to load aromatic ring-containing hydrophobic agent doxorubicin (DOX) via - interaction. The results have shown that the delivery system exhibited enhanced cellular uptake and antitumor efficiency compared with free drugs. This study opens new avenues for the application of hydrophilic polymers in drug delivery.
引用
收藏
页码：8218 / 8221
页数：4
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