Molecular determinants of Listeria monocytogenes virulence

被引：203
作者：
Dussurget, O [1 ]
Pizarro-Cerda, J [1 ]
Cossart, P [1 ]
机构：
[1] Inst Pasteur, INSERM, U604, Unite Interact Bacteries Cellules, F-75015 Paris, France
来源：
ANNUAL REVIEW OF MICROBIOLOGY | 2004年 / 58卷
关键词：
infectious cycle; virulence factors; genomes; pathophysiology;
D O I：
10.1146/annurev.micro.57.030502.090934
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Listeria monocytogenes is the etiological agent of listeriosis, a severe human foodborne infection characterized by gastroenteritis, meningitis, encephalitis, abortions, and perinatal infections. This gram-positive bacterium is a facultative intracellular pathogen that induces its own uptake into nonphagocytic cells and spreads from cell to cell using an actin-based motility process. This review covers both well-established and recent advances in the characterization of L. monocytogenes virulence determinants and their role in the pathophysiology of listeriosis.
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收藏
页码：587 / 610
页数：24
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