Pd(II)-Catalyzed Synthesis of Carbolines by Iminoannulation of Internal Alkynes via Direct C-H Bond Cleavage Using Dioxygen as Oxidant

被引：127

作者：

Ding, Shengtao ^{[1
]}

Shi, Zhuangzhi ^{[1
]}

Jiao, Ning ^{[1
,2
]}

机构：

[1] Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

[2] Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 07期

基金：

美国国家科学基金会;

关键词：

PALLADIUM-CATALYZED IMINOANNULATION; ANNULATED GAMMA-CARBOLINES; BETA-CARBOLINE; MOLECULAR-OXYGEN; ORGANIC-CHEMICALS; A-C; ALKALOIDS; DERIVATIVES; INDOLES; FUNCTIONALIZATION;

D O I：

10.1021/ol100272s

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A palladium-catalyzed iminoannulation of Internal alkynes via direct C-H bond cleavage was developed. Dioxygen was employed as a clean oxidant In this kind of catalysis. Carbolines were synthesized from tert-butylimines of N-substituted Indole-2-carboxaldehydes or indole-3-carboxaldehydes.

引用

页码：1540 / 1543

页数：4

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