The metabolic syndrome and chronic kidney disease in a Southeast Asian cohort

被引:90
作者
Kitiyakara, C.
Yamwong, S.
Cheepudomwit, S.
Domrongkitchaiporn, S.
Unkurapinun, N.
Pakpeankitvatana, V.
Sritara, P.
机构
[1] Mahidol Univ, Ramathibodi Hosp, Dept Med, Fac Med,Div Nephrol, Bangkok 10110, Thailand
[2] Elect Generating Author Thailand, Elect Med & Hlth Off, Nonthaburi, Thailand
[3] Mahidol Univ, Fac Pharm, Dept Food Chem, Bangkok, Thailand
关键词
obesity; waist circumference; Thai; renal failure; NCEP; IDF;
D O I
10.1038/sj.ki.5002128
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
US adults with metabolic syndrome, as defined by National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria, have been shown to be at increased risk of chronic kidney disease (CKD), but there is limited information in other populations. The relationship between metabolic syndrome and CKD (defined as estimated glomerular filtration rate < 60 ml/min/1.73 m(2)) was examined in a Southeast Asian cohort. This relationship was examined when the subjects (n = 3195) were initially recruited in a cross-sectional analysis. The risks of developing new CKD associated with metabolic syndrome were also examined prospectively in a subgroup ( n 2067) without CKD at entry after 12 years follow-up. Metabolic syndrome was defined according to both NCEP ATP III and the new International Diabetes Federation (IDF) criteria. The prevalence of CKD was 1.6%, and the incidence of new CKD was 6.3%. Metabolic syndrome by NCEP ATP III definition was associated with the increased risk of CKD at baseline (adjusted odds ratio ( OR) 2.48 and 95% confidence interval 1.33-4.62), and of developing new CKD at follow-up (adjusted OR 1.62 and 95% confidence interval 1.00-2.61). There was a significant graded relationship between the number of metabolic syndrome components present and risk of CKD. By contrast, metabolic syndrome by IDF definition was not associated with increased risk of CKD. These results suggest the relationship between CKD and metabolic syndrome in a Southeast Asian population is highly dependent on the criteria used to define metabolic syndrome.
引用
收藏
页码:693 / 700
页数:8
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