Synthesis and antibacterial activities of new 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octan-2,4-dione moiety

被引：3
作者：
Nam, KH
Oh, CH
Ham, YW
Lee, KS
Cho, JH
机构：
[1] HANYANG UNIV, DEPT CHEM, SEOUL 133791, SOUTH KOREA
[2] KOREA INST SCI & TECHNOL, DIV APPL SCI, SEOUL 130650, SOUTH KOREA
来源：
ARCHIV DER PHARMAZIE | 1997年 / 330卷 / 08期
关键词：
carbapenem; antibacterial activity; substituent effect; stereoisomerism;
D O I：
10.1002/ardp.19973300808
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of a new series of 1 beta-methylcarbapenems having a 1,3-diazabicyclo[3.3.0]octane-2,3-dione moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bateria are determined and the effect of substituent on the bicyclic ring as well as stereoisomerism was investigated.
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页码：268 / 270
页数：3
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