Group 3 Pulmonary Hypertension: From Bench to Bedside

被引：40
|
作者：
Singh, Navneet [1 ]
Dorfmuller, Peter [3 ,4 ,5 ]
Shlobin, Oksana A. [6 ]
Ventetuolo, Corey E. [1 ,2 ]
机构：
[1] Brown Univ, Div Pulm Crit Care & Sleep Med, 593 Eddy St,APC 757, Providence, RI 02903 USA
[2] Brown Univ, Dept Hlth Serv Policy & Practice, Providence, RI USA
[3] Univ Giessen, Dept Pathol, Giessen, Germany
[4] Justus Liebig Univ, Marburg Lung Ctr UGMLC, Giessen, Germany
[5] German Ctr Lung Res DZL, Giessen, Germany
[6] Inova Fairfax Hosp, Adv Lung Dis & Transplant Program, Falls Church, VA USA
来源：
CIRCULATION RESEARCH | 2022年 / 130卷 / 09期
关键词：
hypertension; pulmonary; hypoxia; lung diseases; interstitial; prevalence; ventricular dysfunction; right; INHALED NITRIC-OXIDE; ENDOTHELIAL GROWTH-FACTOR; RIGHT-VENTRICULAR DYSFUNCTION; BRAIN NATRIURETIC PEPTIDE; INTERSTITIAL LUNG-DISEASE; SMOKE-INDUCED EMPHYSEMA; TERM OXYGEN-THERAPY; 6-MINUTE WALK TEST; ANIMAL-MODELS; ARTERIAL-HYPERTENSION;
D O I：
10.1161/CIRCRESAHA.121.319970
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pulmonary hypertension (PH) because of chronic lung disease is categorized as Group 3 PH in the most recent classification system. Prevalence of these diseases is increasing over time, creating a growing need for effective therapeutic options. Recent approval of the first pulmonary arterial hypertension therapy for the treatment of Group 3 PH related to interstitial lung disease represents an encouraging advancement. This review focuses on molecular mechanisms contributing to pulmonary vasculopathy in chronic hypoxia, the pathology and epidemiology of Group 3 PH, the right ventricular dysfunction observed in this population and clinical trial data that inform the use of pulmonary vasodilators in Group 3 PH.
引用
收藏
页码：1404 / 1422
页数：19
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