Folic acid-conjugated chitosan oligosaccharide-magnetic halloysite nanotubes as a delivery system for camptothecin

被引：97

作者：

Dramou, Pierre ^{[1
]}

Fizir, Meriem ^{[1
]}

Taleb, Abdoh ^{[2
]}

Itatahine, Asma ^{[1
]}

Dahiru, Nasiru Sintali ^{[1
]}

Mehdi, Yamina Ait ^{[1
]}

Wei, Liu ^{[1
]}

Zhang, Jingyi ^{[1
]}

He, Hua ^{[1
,3
]}

机构：

[1] China Pharmaceut Univ, Sch Sci, Dept Analyt Chem, Nanjing 210009, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Sch Pharm, Dept Pharmacol, Nanjing 210009, Jiangsu, Peoples R China

[3] China Pharmaceut Univ, Minist Educ, Key Lab Drug Qual Control & Pharmacovigilance, 639 Longmian Ave, Nanjing 211198, Jiangsu, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2018年 / 197卷

关键词：

Halloysite nanotubes; Chitosane oligosaccharides; Drug delivery; Magnetic targeting; MESOPOROUS SILICA NANOPARTICLES; DRUG-DELIVERY; TARGETED DELIVERY; SUSTAINED-RELEASE; BLOCK-COPOLYMER; GRAPHENE OXIDE; CLAY NANOTUBES; IN-VITRO; CANCER; CYTOTOXICITY;

D O I：

10.1016/j.carbpol.2018.05.071

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this research, to achieve enhanced intracellular uptake of anticancer drug carriers for efficient chemotherapy, folic acid conjugated chitosan oligosaccharides assembled magnetic halloysite nanotubes (FA-COS/MHNTs) have been tailored as multitask drug delivery system towards camptothecin (CPT). Besides magnetic targeting, the nanocomposites have been reacted with folate complex in order to selectively target cancer cells over expressing the folic acid receptor. HNTs showed to have a high storage capacity of CPT. In vitro, the release results indicated that CPT outflow from the nanocarriers at pH 5 was much greater than that at both pH 6.8 and 7.4. MTT assays showed that the CPT-loaded nanocarriers exhibited stronger cell growth inhibitory against colon cancer cell. Furthermore, nanocarriers gained specificity to target cancer cells because of the enhanced cell uptake mediated by FA moiety and presence of COS. Therefore, the rational designed HNTs nanocarrier for chemotherapy drug showed great potential as tumor-targeted drug delivery carrier.

引用

页码：117 / 127

页数：11

共 60 条

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