Primary Sclerosing Cholangitis and Inflammatory Bowel Disease: A Review

被引：23
作者：
Da Cunha, Teresa [1 ]
Vaziri, Haleh [1 ]
Wu, George Y. [1 ]
机构：
[1] Univ Connecticut, Ctr Hlth, Dept Med, Div Gastroenterol Hepatol, Farmington, CT USA
来源：
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY | 2022年 / 10卷 / 03期
关键词：
Primary sclerosing cholangitis; Cholangitis; Inflammatory bowel disease; Ulcerative colitis; Crohn's disease; GENOME-WIDE ASSOCIATION; BILIARY EPITHELIAL-CELLS; CEREVISIAE ANTIBODIES ASCA; ULCERATIVE-COLITIS; T-CELLS; CLINICAL-SIGNIFICANCE; INCREASED PREVALENCE; CYSTIC-FIBROSIS; CROHNS-DISEASE; HLA ANTIGENS;
D O I：
10.14218/JCTH.2021.00344
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Primary sclerosing cholangitis is a disease affecting around 0.006-0.016% of the population. Of these, around 75% have concomitant inflammatory bowel disease (IBD) according to the most recent epidemiological studies. Several theories have been proposed regarding the pathogenesis of primary sclerosing cholangitis (PSC). These include changes in the function of cholangiocytes, effects of the gut microbiome, association with specific human leukocyte antigen haplotypes and dysregulation of the immune system. However, these do not explain the observed association with IBD. Moreover, there are considerable differences in the frequency and outcomes between patients with PSC and ulcerative colitis compared with PSC and Crohn's disease. The aim of this review is to appraise the most recent studies that have contributed to the epidemiology, advances in the pathophysiology, and characterization of important clinical aspects of the association of PSC and IBD.
引用
收藏
页码：531 / 542
页数：12
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