Diversity of carbapenemases in clinical isolates of Enterobacteriaceae in Croatia-the results of a multicentre study

被引：29

作者：

Atalic, V. Zujic ^{[1
]}

Bedenic, B. ^{[2
,3
]}

Kocsis, E. ^{[4
]}

Mazzariol, A. ^{[4
]}

Sardelic, S. ^{[5
]}

Barisic, M. ^{[6
]}

Plecko, V. ^{[2
,3
]}

Bosnjak, Z. ^{[3
]}

Mijac, M. ^{[3
]}

Jajic, I. ^{[7
]}

Vranic-Ladavac, M. ^{[8
]}

Cornaglia, G. ^{[4
]}

机构：

[1] Publ Hlth Inst Osijek, Dept Microbiol, Osijek, Croatia

[2] Univ Zagreb, Sch Med, Zagreb 41001, Croatia

[3] Univ Hosp Ctr Zagreb, Dept Clin & Mol Microbiol, Zagreb 10000, Croatia

[4] Univ Verona, Dept Pathol & Diagnost, I-37100 Verona, Italy

[5] Univ Hosp Ctr Split, Dept Microbiol, Split, Croatia

[6] Elementary Sch Varazdin, Varazhdin, Croatia

[7] Clin Hosp Ctr Sisters Mercy, Dept Microbiol, Zagreb, Croatia

[8] Publ Hlth Inst Istria Cty, Dept Microbiol, Pula, Croatia

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2014年 / 20卷 / 11期

关键词：

Carbapenems; Enterobacteriaceae; KPC; NDM; VIM; METALLO-BETA-LACTAMASE; KLEBSIELLA-PNEUMONIAE; ESCHERICHIA-COLI; HONG-KONG; IDENTIFICATION; SPREAD; GENES; PCR; PREVALENCE; PLASMIDS;

D O I：

10.1111/1469-0691.12635

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Since the first carbapenem-resistant Klebsiella pneumoniae strain was isolated in 2008, Enterobacteriaceae with reduced susceptibility to one or more carbapenems have emerged sporadically in different geographical regions in Croatia. These observations gave rise to a multicenter study on carbapenem resistance in Enterobacteriaceae from Croatia. Fifty-seven carbapenem-non-susceptible strains of Enterobacteriaceae were collected during 2011-2012 from four large hospital centres in Croatia. Overall, 36 strains produced VIM-1 -lactamase, three produced NDM-1, and one produced KPC-2. A high degree of clonal relatedness was observed in Enterobacter cloacae and Citrobacter freundii strains, in contrast to K.pneumoniae strains. Bla(VIM) genes were located within class1 integron which contained genes encoding resistance to aminoglycosides (aac(A4)). The study found strong association between bla(VIM) and qnr(B6) and between bla(NDM) and qnr(A6) genes.

引用

页码：O894 / O903

页数：10

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