Development and validation of the Uniform Data Set (v3.0) executive function composite score (UDS3-EF)

被引：31

作者：

Staffaroni, Adam M. ^{[1
]}

Asken, Breton M. ^{[1
]}

Casaletto, Kaitlin B. ^{[1
]}

Fonseca, Corrina ^{[1
]}

You, Michelle ^{[1
]}

Rosen, Howard J. ^{[1
]}

Boxer, Adam L. ^{[1
]}

Elahi, Fanny M. ^{[1
]}

Kornak, John ^{[2
]}

Mungas, Dan ^{[3
]}

Kramer, Joel H. ^{[1
]}

机构：

[1] Univ Calif San Francisco UCSF, Dept Neurol, Memory & Aging Ctr, Weill Inst Neurosci, 675 Nelson Rising Lane,Suite 190, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco UCSF, Dept Epidemiol & Biostat, Memory & Aging Ctr, San Francisco, CA USA

[3] Univ Calif Davis, Dept Neurol, Davis, CA 95616 USA

来源：

ALZHEIMERS & DEMENTIA | 2021年 / 17卷 / 04期

关键词：

Alzheimer' s disease; cognition; composite score; executive function; item response theory; mild cognitive impairment; National Alzheimer' s Coordinating Center; uniform data set;

D O I：

10.1002/alz.12214

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Cognitive composite scores offer a means of precisely measuring executive functioning (EF). Methods We developed the Uniform Data Set v3.0 EF composite score (UDS3-EF) in 3507 controls from the National Alzheimer's Coordinating Center dataset using item-response theory and applied nonlinear and linear demographic adjustments. The UDS3-EF was validated with other neuropsychological tests and brain magnetic resonance imaging from independent research cohorts using linear models. Results Final model fit was good-to-excellent: comparative fit index = 0.99; root mean squared error of approximation = 0.057. UDS3-EF scores differed across validation cohorts (controls > mild cognitive impairment > Alzheimer's disease-dementia approximate to behavioral variant frontotemporal dementia; P < 0.001). The UDS3-EF correlated most strongly with other EF tests (beta s = 0.50 to 0.85, Ps < 0.001) and more with frontal, parietal, and temporal lobe gray matter volumes (beta s = 0.18 to 0.33, Ps <= 0.004) than occipital gray matter (beta = 0.12, P = 0.04). The total sample needed to detect a 40% reduction in UDS3-EF change (n = 286) was approximate to 40% of the next best measure (F-words; n = 714). Conclusions The UDS3-EF is well suited to quantify EF in research and clinical trials and offers psychometric and practical advantages over its component tests.

引用

页码：574 / 583

页数：10

共 38 条

[1] Executive function and the frontal lobes: A meta-analytic review [J].