Thwarting Dyskinesia by Targeting mTORC1

被引：6

作者：

Klann, Eric ^{[1
]}

机构：

[1] NYU, Ctr Neural Sci, New York, NY 10003 USA

来源：

SCIENCE SIGNALING | 2009年 / 2卷 / 80期

关键词：

DOPA-INDUCED DYSKINESIA; SYNAPTIC PLASTICITY; TRANSLATIONAL CONTROL; MAMMALIAN TARGET; MEMORY; RAPAMYCIN; KINASE; RAPTOR; PHOSPHORYLATION; MACHINERY;

D O I：

10.1126/scisignal.280pe42

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In a mouse model of Parkinson's disease, new evidence shows that L-DOPA, which is used to treat the symptoms of the disease but also causes dyskinesia, results in a persistent activation of the protein kinase mTOR (mammalian target of rapamycin) in a subset of striatal medium spiny neurons. Moreover, blockade of a specific type of mTOR signaling (mTORC1) prevents the development of dyskinesia, but not the antiakinetic benefits produced by L-DOPA. Thus, mTORC1 may be a viable therapeutic target for dyskinesia caused by L-DOPA treatment in patients with Parkinson's disease.

引用

页数：3

共 20 条

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