miRNAs Participate in MS Pathological Processes and Its Therapeutic Response

被引：32

作者：

Wu, Ting ^{[1
]}

Chen, Guangjie ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Shanghai Inst Immunol, Dept Immunol & Microbiol, Shanghai 200025, Peoples R China

来源：

MEDIATORS OF INFLAMMATION | 2016年 / 2016卷

关键词：

BLOOD-BRAIN-BARRIER; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; NF-KAPPA-B; ADVANCE TRANSLATIONAL RESEARCH; REGULATORY T-CELLS; MULTIPLE-SCLEROSIS; GLATIRAMER ACETATE; TH17; DIFFERENTIATION; EXPRESSION PROFILE; IMMUNE-RESPONSE;

D O I：

10.1155/2016/4578230

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Multiple sclerosis is the most common autoimmune disease of the central nervous system. It is believed that the increased migration of autoreactive lymphocytes across the blood-brain barrier (BBB) may be responsible for axonal demyelination of neurons. In this review, we discuss microRNAs participating in the pathological processes of MS, including periphery inflammation, blood-brain barrier disruption, and CNS lesions, and in its therapeutic response, in order to find biomarkers of disease severity and to predict the response to therapy of the diseases.

引用

页数：9

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