Arsenic trioxide and acute promyelocytic leukemia:: Clinical and biological

被引：0
|
作者：
Chen, Z.
Zhao, W-L.
Shen, Z-X.
Li, J-M.
Chen, S-J.
Zhu, J.
Lallemand-Breittenbach, V.
Zhou, J.
Guillemin, M-C.
Vitoux, D.
de The, H.
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Inst Hematol, Rui Jin Hosp, Sch Med, Shanghai 200025, Peoples R China
[2] Hop St Louis, CNRS, UMR 7151, Hop St Louis, F-75475 Paris, France
来源：
ACUTE PROMYELOCYTIC LEUKEMIA: MOLECULAR GENETICS, MOUSE MODELS AND TARGETED THERAPY | 2007年 / 313卷
关键词：
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Arsenic has recently been identified as an effective drug in the treatment of newly diagnosed and relapsed acute promyelocytic leukemia. Indeed, arsenic trioxide combined with all-trans retinoic acid shows a synergistic effect. Mechanistically, arsenic targets the key leukemogenic protein PML-RAR alpha, setting up a new example of molecular target-based cancer therapy.
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页码：129 / 144
页数：16
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