共 57 条
Human lung and monocyte-derived macrophages differ with regard to the effects of β2-adrenoceptor agonists on cytokine release
被引:18
作者:

Victoni, Tatiana
论文数: 0 引用数: 0
h-index: 0
机构:
Lab Tissue Repair, Lab Histocompatibil & Cryopresevat, Rio De Janeiro, Brazil
Univ Paris Saclay, Univ Versailles St Quentin, UFR Sci Sante Simone Veil, Lab Res Resp Pharmacol UPRES EA220, 11 Rue Guillaume Lenoir, F-92150 Suresnes, France Lab Tissue Repair, Lab Histocompatibil & Cryopresevat, Rio De Janeiro, Brazil

Salvator, Helene
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris Saclay, Univ Versailles St Quentin, UFR Sci Sante Simone Veil, Lab Res Resp Pharmacol UPRES EA220, 11 Rue Guillaume Lenoir, F-92150 Suresnes, France
Foch Hosp, Dept Airway Dis, Suresnes, France Lab Tissue Repair, Lab Histocompatibil & Cryopresevat, Rio De Janeiro, Brazil

Abrial, Charlotte
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris Saclay, Univ Versailles St Quentin, UFR Sci Sante Simone Veil, Lab Res Resp Pharmacol UPRES EA220, 11 Rue Guillaume Lenoir, F-92150 Suresnes, France Lab Tissue Repair, Lab Histocompatibil & Cryopresevat, Rio De Janeiro, Brazil

Brollo, Marion
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris Saclay, Univ Versailles St Quentin, UFR Sci Sante Simone Veil, Lab Res Resp Pharmacol UPRES EA220, 11 Rue Guillaume Lenoir, F-92150 Suresnes, France Lab Tissue Repair, Lab Histocompatibil & Cryopresevat, Rio De Janeiro, Brazil

Sobrino Porto, Luis Cristovao
论文数: 0 引用数: 0
h-index: 0
机构:
Lab Tissue Repair, Lab Histocompatibil & Cryopresevat, Rio De Janeiro, Brazil Lab Tissue Repair, Lab Histocompatibil & Cryopresevat, Rio De Janeiro, Brazil

论文数: 引用数:
h-index:
机构:

Naline, Emmanuel
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris Saclay, Univ Versailles St Quentin, UFR Sci Sante Simone Veil, Lab Res Resp Pharmacol UPRES EA220, 11 Rue Guillaume Lenoir, F-92150 Suresnes, France
Foch Hosp, Dept Airway Dis, Suresnes, France Lab Tissue Repair, Lab Histocompatibil & Cryopresevat, Rio De Janeiro, Brazil

Grassin-Delyle, Stanislas
论文数: 0 引用数: 0
h-index: 0
机构:
Foch Hosp, Dept Airway Dis, Suresnes, France
Univ Paris Saclay, Univ Versailles St Quentin, UFR Sci Sante Simone Veil, INSERM UMR1173, Montigny Le Bretonneux, France
Univ Paris Saclay, Univ Versailles St Quentin, UFR Sci Sante Simone Veil, Mass Spectrometry Facil, Montigny Le Bretonneux, France Lab Tissue Repair, Lab Histocompatibil & Cryopresevat, Rio De Janeiro, Brazil

Devillier, Philippe
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris Saclay, Univ Versailles St Quentin, UFR Sci Sante Simone Veil, Lab Res Resp Pharmacol UPRES EA220, 11 Rue Guillaume Lenoir, F-92150 Suresnes, France
Foch Hosp, Dept Airway Dis, Suresnes, France Lab Tissue Repair, Lab Histocompatibil & Cryopresevat, Rio De Janeiro, Brazil
机构:
[1] Lab Tissue Repair, Lab Histocompatibil & Cryopresevat, Rio De Janeiro, Brazil
[2] Univ Paris Saclay, Univ Versailles St Quentin, UFR Sci Sante Simone Veil, Lab Res Resp Pharmacol UPRES EA220, 11 Rue Guillaume Lenoir, F-92150 Suresnes, France
[3] Foch Hosp, Dept Airway Dis, Suresnes, France
[4] Univ Paris Saclay, Univ Versailles St Quentin, UFR Sci Sante Simone Veil, INSERM UMR1173, Montigny Le Bretonneux, France
[5] Univ Paris Saclay, Univ Versailles St Quentin, UFR Sci Sante Simone Veil, Mass Spectrometry Facil, Montigny Le Bretonneux, France
[6] Univ Bretagne Loire, Univ Rennes 1, INRA, INSERM,Nutr Metab & Canc, Rennes, France
来源:
RESPIRATORY RESEARCH
|
2017年
/
18卷
关键词:
beta(2)-adrenoceptor;
Cytokines;
Lipopolysaccharide;
Lung macrophage;
Monocyte-derived macrophage;
HUMAN ALVEOLAR MACROPHAGES;
OBSTRUCTIVE PULMONARY-DISEASE;
BLOOD MONONUCLEAR-CELLS;
NECROSIS-FACTOR-ALPHA;
ADRENOCEPTOR AGONISTS;
BETA-ADRENOCEPTORS;
INNATE IMMUNITY;
EP4;
RECEPTOR;
TNF-ALPHA;
IN-VITRO;
D O I:
10.1186/s12931-017-0613-y
中图分类号:
R56 [呼吸系及胸部疾病];
学科分类号:
摘要:
Background: beta(2)-adrenoceptor agonists have been shown to reduce the lipopolysaccharide (LPS)-induced cytokine release by human monocyte-derived macrophages (MDMs). We compare the expression of beta(2)-adrenoceptors and the inhibitory effect of formoterol and salmeterol on the LPS-induced release of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta, IL-6 and a range of chemokines (CCL2, 3, 4, and IL-8) by human lung macrophages (LMs) and MDMs. Methods: LMs were isolated from patients undergoing resection and MDMs were obtained from blood monocytes in the presence of GM-CSF. LMs and MDMs were incubated in the absence or presence of formoterol or salmeterol prior to stimulation with LPS. The effects of formoterol were also assessed in the presence of the phosphodiesterase inhibitor roflumilast. Results: LPS-induced cytokine production was higher in LMs than in MDMs. Salmeterol and formoterol exerted an inhibitory effect on the LPS-induced production of TNF-alpha, IL-6, CCL2, CCL3, and CCL4 in MDMs. In contrast, the beta(2)-adrenoceptor agonists were devoid of any effect on LMs-even in the presence of roflumilast. The expression of beta(2)-adrenergic receptors was detected on Western blots in MDMs but not in LMs. Conclusions: Concentrations of beta(2)-adrenoceptor agonists that cause relaxation of the human bronchus can inhibit cytokine production by LPS-stimulated MDMs but not by LMs.
引用
收藏
页数:10
相关论文
共 57 条
- [1] The Beta-2-Adrenoreceptor Agonists, Formoterol and Indacaterol, but Not Salbutamol, Effectively Suppress the Reactivity of Human Neutrophils In Vitro[J]. MEDIATORS OF INFLAMMATION, 2014, 2014Anderson, Ronald论文数: 0 引用数: 0 h-index: 0机构: Univ Pretoria, MRC, Dept Immunol, Unit Inflammat & Immun,Fac Hlth Sci, ZA-0001 Pretoria, South Africa Univ Pretoria, MRC, Dept Immunol, Unit Inflammat & Immun,Fac Hlth Sci, ZA-0001 Pretoria, South AfricaTheron, Annette J.论文数: 0 引用数: 0 h-index: 0机构: Univ Pretoria, MRC, Dept Immunol, Unit Inflammat & Immun,Fac Hlth Sci, ZA-0001 Pretoria, South Africa Natl Hlth Lab Serv, Tshwane Acad Div, ZA-0001 Pretoria, South Africa Univ Pretoria, MRC, Dept Immunol, Unit Inflammat & Immun,Fac Hlth Sci, ZA-0001 Pretoria, South AfricaSteel, Helen C.论文数: 0 引用数: 0 h-index: 0机构: Univ Pretoria, MRC, Dept Immunol, Unit Inflammat & Immun,Fac Hlth Sci, ZA-0001 Pretoria, South Africa Univ Pretoria, MRC, Dept Immunol, Unit Inflammat & Immun,Fac Hlth Sci, ZA-0001 Pretoria, South AfricaDurandt, Chrisna论文数: 0 引用数: 0 h-index: 0机构: Univ Pretoria, MRC, Dept Immunol, Unit Inflammat & Immun,Fac Hlth Sci, ZA-0001 Pretoria, South Africa Univ Pretoria, MRC, Dept Immunol, Unit Inflammat & Immun,Fac Hlth Sci, ZA-0001 Pretoria, South AfricaTintinger, Gregory R.论文数: 0 引用数: 0 h-index: 0机构: Univ Pretoria, MRC, Dept Immunol, Unit Inflammat & Immun,Fac Hlth Sci, ZA-0001 Pretoria, South Africa Univ Pretoria, MRC, Dept Immunol, Unit Inflammat & Immun,Fac Hlth Sci, ZA-0001 Pretoria, South AfricaFeldman, Charles论文数: 0 引用数: 0 h-index: 0机构: Univ Witwatersrand, Fac Hlth Sci, Dept Internal Med, Div Pulmonol, ZA-2193 Johannesburg, South Africa Charlotte Maxeke Johannesburg Acad Hosp, ZA-2193 Johannesburg, South Africa Univ Pretoria, MRC, Dept Immunol, Unit Inflammat & Immun,Fac Hlth Sci, ZA-0001 Pretoria, South Africa
- [2] International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors[J]. PHARMACOLOGICAL REVIEWS, 2014, 66 (01) : 1 - 79Bachelerie, Francoise论文数: 0 引用数: 0 h-index: 0机构: Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, France Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceBen-Baruch, Adit论文数: 0 引用数: 0 h-index: 0机构: Tel Aviv Univ, George S Wise Fac Life Sci, Dept Cell Res & Immunol, IL-69978 Tel Aviv, Israel Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceBurkhardt, Amanda M.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92717 USA Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, France论文数: 引用数: h-index:机构:Farber, Joshua M.论文数: 0 引用数: 0 h-index: 0机构: NIAID, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceGraham, Gerard J.论文数: 0 引用数: 0 h-index: 0机构: Univ Glasgow, Inst Infect Immun & Inflammat, Coll Med Vet & Life Sci, Glasgow Biomed Res Ctr, Glasgow, Lanark, Scotland Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceHoruk, Richard论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Davis, Dept Pharmacol, Davis, CA 95616 USA Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceSparre-Ulrich, Alexander Hovard论文数: 0 引用数: 0 h-index: 0机构: Univ Copenhagen, Mol Pharmacol Lab, Dept Neurosci & Pharmacol, Fac Hlth & Med Sci, Copenhagen, Denmark Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, France论文数: 引用数: h-index:机构:Luster, Andrew D.论文数: 0 引用数: 0 h-index: 0机构: Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Immunol & Inflammatory Dis,Div Rheumatol Alle, Boston, MA USA Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, France论文数: 引用数: h-index:机构:Matsushima, Kouji论文数: 0 引用数: 0 h-index: 0机构: Univ Tokyo, Sch Med, Dept Mol Prevent Med, Tokyo 113, Japan Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceMurphy, Philip M.论文数: 0 引用数: 0 h-index: 0机构: NIAID, Lab Mol Immunol, NIH, Bethesda, MD 20892 USA Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, France论文数: 引用数: h-index:机构:论文数: 引用数: h-index:机构:Power, Christine A.论文数: 0 引用数: 0 h-index: 0机构: Merck Serono SA, Geneva Res Ctr, Geneva, Switzerland Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceProudfoot, Amanda E. I.论文数: 0 引用数: 0 h-index: 0机构: NovImmune SA, Geneva, Switzerland Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceRosenkilde, Mette M.论文数: 0 引用数: 0 h-index: 0机构: Univ Copenhagen, Mol Pharmacol Lab, Dept Neurosci & Pharmacol, Fac Hlth & Med Sci, Copenhagen, Denmark Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceRot, Antal论文数: 0 引用数: 0 h-index: 0机构: Univ Birmingham, Med Res Council, Ctr Immune Regulat, Inst Biomed Res,Sch Infect & Immun, Birmingham, W Midlands, England Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceSozzani, Silvano论文数: 0 引用数: 0 h-index: 0机构: Univ Brescia, Dept Mol & Translat Med, Brescia, Italy Humanitas Clin & Res Ctr, Rozzano, Italy Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceThelen, Marcus论文数: 0 引用数: 0 h-index: 0机构: Inst Res Biomed, Bellinzona, Switzerland Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceYoshie, Osamu论文数: 0 引用数: 0 h-index: 0机构: Kinki Univ, Dept Microbiol, Fac Med, Osaka, Japan Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, FranceZlotnik, Albert论文数: 0 引用数: 0 h-index: 0机构: Univ Calif Irvine, Dept Physiol & Biophys, Irvine, CA 92717 USA Univ Paris 11, LERMIT, INSERM, UMR S996, Clamart, France
- [3] INHIBITORY ACTIONS OF SALMETEROL ON HUMAN AIRWAY MACROPHAGES AND BLOOD MONOCYTES[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 264 (03) : 301 - 306BAKER, AJ论文数: 0 引用数: 0 h-index: 0机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT CLIN PHARMACOL,LONDON W12 0NN,ENGLANDPALMER, J论文数: 0 引用数: 0 h-index: 0机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT CLIN PHARMACOL,LONDON W12 0NN,ENGLANDJOHNSON, M论文数: 0 引用数: 0 h-index: 0机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT CLIN PHARMACOL,LONDON W12 0NN,ENGLANDFULLER, RW论文数: 0 引用数: 0 h-index: 0机构: HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT CLIN PHARMACOL,LONDON W12 0NN,ENGLAND
- [4] The cytokine network in asthma and chronic obstructive pulmonary disease[J]. JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (11) : 3546 - 3556Barnes, Peter J.论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Airway Dis Sect, London SW3 6LY, England Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Airway Dis Sect, London SW3 6LY, England
- [5] Effect of β-agonists on inflammation cells[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1999, 104 (02) : S10 - S17Barnes, PJ论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Dept Thorac Med, Natl Heart & Lung Inst, London SW3 6LY, England Univ London Imperial Coll Sci Technol & Med, Dept Thorac Med, Natl Heart & Lung Inst, London SW3 6LY, England
- [6] LOCALIZATION OF BETA-ADRENORECEPTORS IN MAMMALIAN LUNG BY LIGHT MICROSCOPIC AUTORADIOGRAPHY[J]. NATURE, 1982, 299 (5882) : 444 - 447BARNES, PJ论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,DEPT OBSTET & GYNECOL & REPROD SCI,SAN FRANCISCO,CA 94143 UNIV CALIF SAN FRANCISCO,DEPT OBSTET & GYNECOL & REPROD SCI,SAN FRANCISCO,CA 94143BASBAUM, CB论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,DEPT OBSTET & GYNECOL & REPROD SCI,SAN FRANCISCO,CA 94143 UNIV CALIF SAN FRANCISCO,DEPT OBSTET & GYNECOL & REPROD SCI,SAN FRANCISCO,CA 94143NADEL, JA论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,DEPT OBSTET & GYNECOL & REPROD SCI,SAN FRANCISCO,CA 94143 UNIV CALIF SAN FRANCISCO,DEPT OBSTET & GYNECOL & REPROD SCI,SAN FRANCISCO,CA 94143ROBERTS, JM论文数: 0 引用数: 0 h-index: 0机构: UNIV CALIF SAN FRANCISCO,DEPT OBSTET & GYNECOL & REPROD SCI,SAN FRANCISCO,CA 94143 UNIV CALIF SAN FRANCISCO,DEPT OBSTET & GYNECOL & REPROD SCI,SAN FRANCISCO,CA 94143
- [7] Effects of air pollutants on innate immunity: The role of Toll-like receptors and nucleotide-binding oligomerization domain-like receptors[J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2012, 129 (01) : 14 - 26Bauer, Rebecca N.论文数: 0 引用数: 0 h-index: 0机构: Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27515 USA Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27515 USADiaz-Sanchez, David论文数: 0 引用数: 0 h-index: 0机构: US EPA, Natl Hlth & Environm Effects, Res Lab, Res Triangle Pk, NC 27711 USA Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27515 USAJaspers, Ilona论文数: 0 引用数: 0 h-index: 0机构: Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27515 USA Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA Univ N Carolina, Dept Pediat, Chapel Hill, NC USA Univ N Carolina, Curriculum Toxicol, Chapel Hill, NC 27515 USA
- [8] Anti-inflammatory effects of PGE2 in the lung: role of the EP4 receptor subtype[J]. THORAX, 2015, 70 (08) : 740 - 747Birrell, Mark A.论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, England MRC Asthma UK Ctr Allerg Mech Asthma, London, England Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, EnglandMaher, Sarah A.论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, EnglandDekkak, Bilel论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, EnglandJones, Victoria论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, EnglandWong, Sissie论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, EnglandBrook, Peter论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, England Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, EnglandBelvisi, Maria G.论文数: 0 引用数: 0 h-index: 0机构: Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, England MRC Asthma UK Ctr Allerg Mech Asthma, London, England Univ London Imperial Coll Sci Technol & Med, Fac Med, Natl Heart & Lung Inst, Dept Resp Pharmacol, London SW7 2AZ, England
- [9] Anti-inflammatory effects of β2 adrenergic receptor agonists in experimental acute lung injury[J]. FASEB JOURNAL, 2012, 26 (05) : 2137 - 2144Bosmann, Markus论文数: 0 引用数: 0 h-index: 0机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USAGrailer, Jamison J.论文数: 0 引用数: 0 h-index: 0机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USAZhu, Ketong论文数: 0 引用数: 0 h-index: 0机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USAMatthay, Michael A.论文数: 0 引用数: 0 h-index: 0机构: Univ Calif San Francisco, Dept Med & Anesthesia, San Francisco, CA 94143 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USASarma, J. Vidya论文数: 0 引用数: 0 h-index: 0机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USAZetoune, Firas S.论文数: 0 引用数: 0 h-index: 0机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USAWard, Peter A.论文数: 0 引用数: 0 h-index: 0机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
- [10] Pharmacological Characterization of Olodaterol, a Novel Inhaled β2-Adrenoceptor Agonist Exerting a 24-Hour-Long Duration of Action in Preclinical Models[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 334 (01) : 53 - 62Bouyssou, T.论文数: 0 引用数: 0 h-index: 0机构: Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, GermanyCasarosa, P.论文数: 0 引用数: 0 h-index: 0机构: Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, GermanyNaline, E.论文数: 0 引用数: 0 h-index: 0机构: Univ Versailles, Hop Foch, Unite Propre Rech & Enseignement Super EA220, Suresnes, France Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, GermanyPestel, S.论文数: 0 引用数: 0 h-index: 0机构: Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, GermanyKonetzki, I.论文数: 0 引用数: 0 h-index: 0机构: Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, GermanyDevillier, P.论文数: 0 引用数: 0 h-index: 0机构: Univ Versailles, Hop Foch, Unite Propre Rech & Enseignement Super EA220, Suresnes, France Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, GermanySchnapp, A.论文数: 0 引用数: 0 h-index: 0机构: Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany Boehringer Ingelheim Pharma GmbH & Co KG, Biberach, Germany