Role of the MAPK/cJun NH2-terminal kinase signaling pathway in starvation-induced autophagy

被引：35

作者：

Barutcu, Seda Avcioglu ^{[1
]}

Girnius, Nomeda ^{[1
]}

Vernia, Santiago ^{[1
]}

Davis, Roger J. ^{[1
,2
,3
]}

机构：

[1] Univ Massachusetts, Med Sch, Program Mol Med, Worcester, MA 01605 USA

[2] Howard Hughes Med Inst, Worcester, MA USA

[3] Imperial Coll London, MRC London Inst Med Sci, Hammersmith Hosp Campus,Du Cane Rd, London W12 0NN, England

来源：

AUTOPHAGY | 2018年 / 14卷 / 09期

基金：

美国国家卫生研究院;

关键词：

Epithelial cell; fibroblast; hepatocyte; MAPK8; MAPK9; MTOR; N-TERMINAL KINASE; PROTEIN-KINASE; JNK1-MEDIATED PHOSPHORYLATION; SUPPRESSES AUTOPHAGY; UP-REGULATION; BCL-XL; JNK; APOPTOSIS; INHIBITION; ACTIVATION;

D O I：

10.1080/15548627.2018.1466013

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is required for cellular homeostasis and can determine cell viability in response to stress. It is established that MTOR is a master regulator of starvation-induced macroautophagy/autophagy, but recent studies have also implicated an essential role for the MAPK8/cJun NH2-terminal kinase 1 signal transduction pathway. We found that MAPK8/JNK1 and MAPK9/JNK2 were not required for autophagy caused by starvation or MTOR inhibition in murine fibroblasts and epithelial cells. These data demonstrate that MAPK8/9 has no required role in starvation-induced autophagy. We conclude that the role of MAPK8/9 in autophagy may be context-dependent and more complex than previously considered.

引用

页码：1586 / 1595

页数：10

共 57 条

[1] RNase L Induces Autophagy via c-Jun N-terminal Kinase and Double-stranded RNA-dependent Protein Kinase Signaling Pathways [J].

Adnan, Mohammad ;

Malathi, Siddiqui Krishnamurthy .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (52) :43651-43664

[2] The specificities of protein kinase inhibitors: an update [J].

Bain, J ;

McLauchlan, H ;

Elliott, M ;

Cohen, P .

BIOCHEMICAL JOURNAL, 2003, 371 :199-204

[3] Suppression of MAPK/JNK-MTORC1 signaling leads to premature loss of organelles and nuclei by autophagy during terminal differentiation of lens fiber cells [J].

Basu, Subhasree ;

Rajakaruna, Suren ;

Reyes, Beverly ;

Van Bockstaele, Elisabeth ;

Menko, A. Sue .

AUTOPHAGY, 2014, 10 (07) :1193-1211

[4] The PEA-15 Protein Regulates Autophagy via Activation of JNK [J].

Boeck, Barbara C. ;

Tagscherer, Katrin E. ;

Fassl, Anne ;

Kraemer, Anika ;

Oehme, Ina ;

Zentgraf, Hans-Walter ;

Keith, Martina ;

Roth, Wilfried .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (28) :21644-21654

[5] The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras [J].

Byun, Joo-Yun ;

Yoon, Chang-Hwan ;

An, Sungkwan ;

Park, In-Chul ;

Kang, Chang-Mo ;

Kim, Min-Jung ;

Lee, Su-Jae .

CARCINOGENESIS, 2009, 30 (11) :1880-1888

[6] JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure [J].

Chaanine, A. H. ;

Jeong, D. ;

Liang, L. ;

Chemaly, E. R. ;

Fish, K. ;

Gordon, R. E. ;

Hajjar, R. J. .

CELL DEATH & DISEASE, 2012, 3 :e265-e265

[7] Palmitate induces autophagy in pancreatic β-cells via endoplasmic reticulum stress and its downstream JNK pathway [J].

Chen, Ying-Ying ;

Sun, Lian-Qing ;

Wang, Bao-An ;

Zou, Xiao-Man ;

Mu, Yi-Ming ;

Lu, Ju-Ming .

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 2013, 32 (06) :1401-1406

[8] Autophagy: in sickness and in health [J].

Cuervo, AM .

TRENDS IN CELL BIOLOGY, 2004, 14 (02) :70-77

[9] Suppression of p53-dependent senescence by the JNK signal transduction pathway [J].

Das, Madhurnita ;

Jiang, Feng ;

Sluss, Hayla K. ;

Zhang, Chao ;

Shokat, Kevan M. ;

Flavell, Richard A. ;

Davis, Roger J. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (40) :15759-15764

[10] Epigenetic Regulation of Autophagy by the Methyltransferase G9a [J].

de Narvajas, Amaia Artal-Martinez ;

Gomez, Timothy S. ;

Zhang, Jin-San ;

Mann, Alexander O. ;

Taoda, Yoshiyuki ;

Gorman, Jacquelyn A. ;

Herreros-Villanueva, Marta ;

Gress, Thomas M. ;

Ellenrieder, Volker ;

Bujanda, Luis ;

Kim, Do-Hyung ;

Kozikowski, Alan P. ;

Koenig, Alexander ;

Billadeau, Daniel D. .

MOLECULAR AND CELLULAR BIOLOGY, 2013, 33 (20) :3983-3993

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