Regional spread of HIV-1 M subtype B in middle-aged patients by random env-C2V4 region sequencing

被引：8

作者：

Stuermer, Martin ^{[1
]}

Zimmermann, Katrin ^{[2
]}

Fritzsche, Carlos ^{[3
]}

Reisinger, Emil ^{[3
]}

Doelken, Gottfried ^{[4
]}

Berger, Annemarie ^{[1
]}

Doerr, Hans W. ^{[1
]}

Eberle, Josef ^{[5
]}

Guertler, Lutz G. ^{[1
,2
]}

机构：

[1] Univ Hosp Frankfurt, Inst Med Virol, D-69596 Frankfurt, Germany

[2] Univ Hosp Greifswald, Friedrich Loeffler Inst Med Microbiol, D-17489 Greifswald, Germany

[3] Univ Rostock, Clin Internal Med & Trop Med, Rostock, Germany

[4] Univ Hosp Greifswald, Clin Internal Med C, Greifswald, Germany

[5] Univ Munich, Max Von Pettenkofer Inst, D-80336 Munich, Germany

来源：

MEDICAL MICROBIOLOGY AND IMMUNOLOGY | 2010年 / 199卷 / 02期

关键词：

HIV transmission; Epidemiology; Cluster; Risky behaviour; Local outbreak; Middle-aged people; IMMUNODEFICIENCY-VIRUS TYPE-1; TRANSMISSION CLUSTER; INFECTIONS; STRATEGIES; ADULTS; RATES; MEN;

D O I：

10.1007/s00430-010-0145-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A transmission cluster of HIV-1 M:B was identified in 11 patients with a median age of 52 (range 26-65) in North-East Germany by C2V4 region sequencing of the env gene of HIV-1, who-except of one-were not aware of any risky behaviour. The 10 male and 1 female patients deteriorated immunologically, according to their information made available, within 4 years after a putative HIV acquisition. Nucleic acid sequence analysis showed a R5 virus in all patients and in 7 of 11 a crown motif of the V3 loop, GPGSALFTT, which is found rarely. Analysis of formation of this cluster showed that there is still a huge discrepancy between awareness and behaviour regarding HIV transmission in middle-aged patients, and that a local outbreak can be detected by nucleic acid analysis of the hypervariable env region.

引用

页码：123 / 128

页数：6

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