Allogeneic Hematopoietic Stem Cell Transplantation for Adults with Sickle Cell Disease

被引：9

作者：

Saraf, Santosh L. ^{[1
]}

Rondelli, Damiano ^{[1
]}

机构：

[1] Univ Illinois, Dept Med, Div Hematol & Oncol, Chicago, IL 60612 USA

来源：

JOURNAL OF CLINICAL MEDICINE | 2019年 / 8卷 / 10期

关键词：

sickle cell disease; transplantation; BONE-MARROW-TRANSPLANTATION; QUALITY-OF-LIFE; MATCHED RELATED DONORS; PULMONARY-HYPERTENSION; REDUCED-INTENSITY; UNITED-STATES; RISK-FACTORS; HEALTH-CARE; MORTALITY; ANEMIA;

D O I：

10.3390/jcm8101565

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sickle cell disease (SCD) is an inherited red blood cell disorder that leads to substantial morbidity and early mortality. Acute and chronic SCD-related complications increase with older age, and therapies are urgently needed to treat adults. Allogeneic hematopoietic stem cell transplantation (HSCT) is a curative therapy, but has been used less frequently in adults compared to children. This is, in part, due to (1) greater chronic organ damage, limiting tolerability to myeloablative conditioning regimens, (2) a higher rate of HSCT-related complications in adults versus children with SCD, and (3) limited coverage by public and private health insurance. Newer approaches using nonmyeloablative and reduced-intensity conditioning HSCT regimens have demonstrated better safety and tolerability, with high rates of stable engraftment in SCD adults. This review will focus on the impacts of HSCT, using more contemporary approaches to SCD-related complications in adults.

引用

页数：17

共 82 条

[11] A survey on patient perception of reduced-intensity transplantation in adults with sickle cell disease [J].

Chakrabarti, S. ;

Bareford, D. .

BONE MARROW TRANSPLANTATION, 2007, 39 (08) :447-451

[12] EFFECT OF HYDROXYUREA ON THE FREQUENCY OF PAINFUL CRISES IN SICKLE-CELL-ANEMIA [J].

CHARACHE, S ;

TERRIN, ML ;

MOORE, RD ;

DOVER, GJ ;

BARTON, FB ;

ECKERT, SV ;

MCMAHON, RP ;

BONDS, DR ;

ORRINGER, E ;

JONES, S ;

STRAYHORN, D ;

ROSSE, W ;

PHILLIPS, G ;

PEACE, D ;

JOHNSONTELFAIR, A ;

MILNER, P ;

KUTLAR, A ;

TRACY, A ;

BALLAS, SK ;

ALLEN, GE ;

MOSHANG, J ;

SCOTT, B ;

STEINBERG, M ;

ANDERSON, A ;

SABAHI, V ;

PEGELOW, C ;

TEMPLE, D ;

CASE, E ;

HARRELL, R ;

CHILDERIE, S ;

EMBURY, S ;

SCHMIDT, B ;

DAVIES, D ;

KOSHY, M ;

TALISCHYZAHED, N ;

DORN, L ;

PENDARVIS, G ;

MCGEE, M ;

TELFER, M ;

DAVIS, A ;

CASTRO, O ;

FINKE, H ;

PERLIN, E ;

SITEMAN, J ;

GASCON, P ;

DIPAOLO, P ;

GARGIULO, S ;

ECKMAN, J ;

BAILEY, JH ;

PLATT, A .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 332 (20) :1317-1322

[13] Haematological determinants of cardiac involvement in adults with sickle cell disease [J].

Damy, Thibaud ;

Bodez, Diane ;

Habibi, Anoosha ;

Guellich, Aziz ;

Rappeneau, Stephane ;

Inamo, Jocelyn ;

Guendouz, Soulef ;

Gellen-Dautremer, Justine ;

Pissard, Serge ;

Loric, Sylvain ;

Wagner-Ballon, Orianne ;

Godeau, Bertrand ;

Adnot, Serge ;

Dubois-Rande, Jean-Luc ;

Hittinger, Luc ;

Galacteros, Frederic ;

Bartolucci, Pablo .

EUROPEAN HEART JOURNAL, 2016, 37 (14) :1158-1167

[14] Pain and opioid use after reversal of sickle cell disease following HLA-matched sibling haematopoietic stem cell transplant [J].

Darbari, Deepika S. ;

Liljencrantz, Jaquette ;

Ikechi, Austin ;

Martin, Staci ;

Roderick, Marie Claire ;

Fitzhugh, Courtney D. ;

Tisdale, John F. ;

Thein, Swee Lay ;

Hsieh, Matthew .

BRITISH JOURNAL OF HAEMATOLOGY, 2019, 184 (04) :690-693

[15] Severe Painful Vaso-Occlusive Crises and Mortality in a Contemporary Adult Sickle Cell Anemia Cohort Study [J].

Darbari, Deepika S. ;

Wang, Zhengyuan ;

Kwak, Minjung ;

Hildesheim, Mariana ;

Nichols, James ;

Allen, Darlene ;

Seamon, Catherine ;

Peters-Lawrence, Marlene ;

Conrey, Anna ;

Hall, Mary K. ;

Kato, Gregory J. ;

Taylor, James G. .

PLOS ONE, 2013, 8 (11)

[16] Pulmonary hypertension associated with sickle cell disease: Clinical and laboratory endpoints and disease outcomes [J].

De Castro, Laura M. ;

Jonassaint, Jude C. ;

Graham, Felicia L. ;

Ashley-Koch, Allison ;

Telen, Marilyn J. .

AMERICAN JOURNAL OF HEMATOLOGY, 2008, 83 (01) :19-25

[17] Mortality in children, adolescents and adults with sickle cell anemia in Rio de Janeiro, Brazil [J].

de Castro Lobo, Clarisse Lopes ;

Nascimento, Emilia Matos ;

Carvalho de Jesus, Leonardo Jose ;

de Freitas, Thiago Gotelip ;

Lugon, Jocemir Ronaldo ;

Ballas, Samir K. .

HEMATOLOGY TRANSFUSION AND CELL THERAPY, 2018, 40 (01) :37-42

[18] Haploidentical Bone Marrow Transplantation with Post-Transplantation Cyclophosphamide Plus Thiotepa Improves Donor Engraftment in Patients with Sickle Cell Anemia: Results of an International Learning Collaborative [J].

de la Fuente, Josu ;

Dhedin, Nathalie ;

Koyama, Tatsuki ;

Bernaudin, Francoise ;

Kuentz, Mathieu ;

Karnik, Leena ;

Socie, Gerard ;

Culos, Kathryn A. ;

Brodsky, Robert A. ;

DeBaun, Michael R. ;

Kassim, Adetola A. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2019, 25 (06) :1197-1209

[19] Decreased median survival of adults with sickle cell disease after adjusting for left truncation bias: a pooled analysis [J].

DeBaun, Michael R. ;

Ghafuri, Djamila L. ;

Rodeghier, Mark ;

Maitra, Poulami ;

Chaturvedi, Shruti ;

Kassim, Adetola ;

Ataga, Kenneth I. .

BLOOD, 2019, 133 (06) :615-617

[20] Long-term course of patients with primary ocular adnexal MALT lymphoma: a large single-institution cohort study [J].

Desai, Amrita ;

Joag, Madhura G. ;

Lekakis, Lazaros ;

Chapman, Jennifer R. ;

Vega, Francisco ;

Tibshirani, Robert ;

Tse, David ;

Markoe, Arnold ;

Lossos, Izidore S. .

BLOOD, 2017, 129 (03) :324-332

← 1 2 3 4 5 6 7 8 9 →