The Role and Function of Mucins and Its Relationship to Inflammatory Bowel Disease

被引：82
作者：
Kang, Youra [1 ]
Park, Hyeonjeong [1 ]
Choe, Byung-Ho [2 ]
Kang, Ben [2 ]
机构：
[1] Kyungpook Natl Univ, Cell & Matrix Res Inst, Sch Med, Daegu, South Korea
[2] Kyungpook Natl Univ, Sch Med, Dept Pediat, Daegu, South Korea
来源：
FRONTIERS IN MEDICINE | 2022年 / 9卷
基金：
新加坡国家研究基金会;
关键词：
mucins; mucus; inflammatory bowel diseases; ulcerative colitis; Crohn's disease; INTESTINAL MUCIN; GENE-EXPRESSION; INCREASED SUSCEPTIBILITY; ULCERATIVE-COLITIS; TREFOIL FACTORS; TNF-ALPHA; MOLECULAR-CLONING; EPITHELIAL-CELLS; CROHNS-DISEASE; COLONIC MUCIN;
D O I：
10.3389/fmed.2022.848344
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Mucus is present throughout the gastrointestinal tract and is essential for regulating gut microbiota homeostasis and preventing disease by protecting the gastrointestinal barrier from microorganisms, pathogens and toxins or other irritants. Mucin (MUC)-2 is a secreted protein produced by epithelial goblet cells as the main component of mucus. Defects in the gastrointestinal tract, such as inflammation and ulcers, cause damage to the mucus barrier, which can worsen mucus quality and reduce mucus production. Therefore, we would like to review the characteristics of MUC2 and its role in intestinal disorders and highlight the importance of further studies. We also investigated whether the role of MUC2 differs between children and adults, ulcerative colitis (UC) and Crohn's disease (CD).
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页数：7
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