Inflammation: a trigger for acute coronary syndrome

被引：1

作者：

Sager, Hendrik B. ^{[1
]}

Nahrendorf, Matthias ^{[2
,3
,4
]}

机构：

[1] German Heart Ctr Munich, Dept Cardiovasc Dis, Lazarettstr 36, D-80636 Munich, Germany

[2] Harvard Med Sch, Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA USA

[3] Harvard Med Sch, Massachusetts Gen Hosp, Dept Imaging, Boston, MA USA

[4] Harvard Med Sch, Massachusetts Gen Hosp, Cardiovasc Res Ctr, Boston, MA USA

来源：

QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2016年 / 60卷 / 03期

关键词：

Atherosclerosis; Inflammation; Precipitating factors; Acute coronary syndrome; HEMATOPOIETIC STEM; BONE-MARROW; ATHEROSCLEROTIC LESIONS; MACROPHAGE ACCUMULATION; MYOCARDIAL-INFARCTION; MONOCYTE RECRUITMENT; LY-6C(HI) MONOCYTES; CHEMOKINE RECEPTORS; ADHESION MOLECULES; P-SELECTIN;

D O I：

暂无

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Atherosclerosis is a chronic inflammatory disease of the vessel wall and a major cause of death worldwide. One of atherosclerosis' most dreadful complications are acute coronary syndromes that comprise ST-segment elevation myocardial infarction, non-ST-segment elevation myocardial infarction, and unstable angina. We now understand that inflammation substantially contributes to the initiation, progression, and destabilization of atherosclerosis. In this review, we will focus on the role of inflammatory leukocytes, which are the cellular protagonists of vascular inflammation, in triggering disease progression and, ultimately, the destabilization that causes acute coronary syndromes.

引用

页码：185 / 193

页数：9

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